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ARS Home » Midwest Area » West Lafayette, Indiana » Crop Production and Pest Control Research » Research » Publications at this Location » Publication #390909
Research Project: Genetic Enhancement of Seed Quality and Plant Health Traits, and Designing Soybeans with Improved Functionality

Location: Crop Production and Pest Control Research

Title: A giant chimeric NLR gene responsible for broad spectrum resistance to a soybean pathogen

Author
item WANG, WEIDONG - Purdue University
item CHEN, LIYANG - Purdue University
item FENGLER, KEVIN - Corteva Agriscience
item BOLAR, JOY - Corteva Agriscience
item LLACA, VICTOR - Corteva Agriscience
item WANG, XUTONG - Purdue University
item CLARK, CHANCELOR - Purdue University
item Fleury, Tomara
item MYRVOLD, JON - Corteva Agriscience
item ONEAL, DAVID - Corteva Agriscience
item VAN DYK, DALEEN - Corteva Agriscience
item HUDSON, ASHLEY - Corteva Agriscience
item MUNVOLK, JESSE - Corteva Agriscience
item BAUMGARTEN, ANDY - Corteva Agriscience
item THOMPSON, JEFF - Corteva Agriscience
item Cai, Guohong
item CRASTA, OSWALD - Corteva Agriscience
item AGGARWAL, RAJAT - Corteva Agriscience
item MA, JIANXIN - Purdue University

Submitted to: Annual International Plant & Animal Genome Conference
Publication Type: Abstract Only
Publication Acceptance Date: 12/15/2021
Publication Date: 1/8/2022
Citation: Wang, W., Chen, L., Fengler, K., Bolar, J., Llaca, V., Wang, X., Clark, C.B., Fleury, T.J., Myrvold, J., Oneal, D., Van Dyk, D., Hudson, A., Munvolk, J., Baumgarten, A., Thompson, J., Cai, G., Crasta, O., Aggarwal, R., Ma, J. 2022. A giant chimeric NLR gene responsible for broad spectrum resistance to a soybean pathogen. [ABSTRACT] Annual International Plant & Animal Genome Conference.

Interpretive Summary:

Technical Abstract: Phytophthora root and stem rot caused by Phytophthora sojae is a destructive soybean soil-borne disease found worldwide. Discovery of genes conferring broad-spectrum resistance to the pathogen is a need to prevent the outbreak of the disease. Here, we show that soybean Rps11 is a 27.7-kb nucleotide-binding site-leucine-rich repeat (NBS-LRR or NLR) gene conferring broad-spectrum resistance to the pathogen. Rps11 is located in a genomic region harboring a cluster of large NLR genes of a single origin in soybean, and is derived from rounds of unequal recombination. Such events result in promoter fusion and LRR expansion that may contribute to the broad resistance spectrum. The NLR gene cluster exhibits drastic structural diversification among phylogenetically representative varieties, including gene copy number variation ranging from five to 23 copies, and absence of allelic copies of Rps11 in any of the non-Rps11-donor varieties examined, exemplifying innovative evolution of NLR genes and NLR gene clusters.