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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #389506

Research Project: Energy Met.: Novel Approaches to Facilitating Successful Energy Regulation in Aging--Obesity & Met.: Role of Adipocyte Metabolism in the Development of Obesity and Associated Metabolic Complications

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Physical activity and fat-free mass during growth and in later life

Author
item WESTERTERP, KLAAS - Maastricht University
item YAMADA, YOSUKE - National Institutes Of Biomedical Innovation
item SAGAYAMA, HIROYUKI - University Of Tsukuba
item AINSLIE, PHILIP - Liverpool John Moores University
item ANDERSEN, LENE - University Of Oslo
item ANDERSON, LIAM - Liverpool John Moores University
item ARAB, LENORE - University Of California
item BADDOU, ISSAAD - Universite Ibn Tofail
item BEDU-ADDO, KWEKU - Kwame Nkrumah University Of Science And Technology
item BLAAK, ELLEN - Maastricht University
item BLANC, STEPHANE - University Of Wisconsin
item BONOMI, ALBERTO - Philips Research Eindhoven
item BOUTEN, CARLIJN - Eindhoven University Of Technology
item BOVET, PASCAL - Lausanne University Hospital
item BUCHOWSKI, MACIEJ - Vanderbilt University
item BUTTE, NANCY - Children'S Nutrition Research Center (CNRC)
item CAMPS, STEFAN - Maastricht University
item CLOSE, GRAEME - Liverpool John Moores University
item COOPER, JAMIE - University Of Wisconsin
item DAS, SAI KRUPA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item COOPER, RICHARD - Loyola University
item DUGAS, LARA - Loyola University
item EKELUND, ULF - Norwegian School Of Sport Sciences
item ENTRINGER, SONJA - Berlin Institute Of Health
item FORRESTER, TERRENCE - University Of The West Indies
item FUDGE, BARRY - University Of Glasgow
item GORIS, ANNELIES - Maastricht University
item GURVEN, MICHAEL - University Of California
item HAMBLY, CATHERINE - University Of Aberdeen
item EL HAMDOUCHI, ASMAA - Universite Ibn Tofail
item HOOS, MARIJE - Maastricht University
item HU, SUMEI - Chinese Academy Of Sciences
item JOONAS, NOORJEHAN - Mauritius Ministry Of Health And Wellness
item JOOSEN, ANNEMIEK - Maastricht University
item KATZMARZYK, PETER - Pennington Biomedical Research Center
item KEMPEN, KITTY - Maastricht University
item KIMURA, MISAKA - National Institutes Of Biomedical Innovation
item KRAUS, WILLIAM - Duke University
item KUSHNER, ROBERT - Northwestern University
item LAMBERT, ESTELLE - University Of Cape Town
item LEONARD, WILLIAM - Northwestern University
item LESSAN, NADER - Imperial College
item MARTIN, CORBY - Pennington Biomedical Research Center
item MEDIN, ANINE - University Of Oslo
item MEIJER, ERWIN - Maastricht University
item MOREHEN, JAMES - The Fa Group
item MORTON, JAMES - Liverpool John Moores University
item NEUHOUSER, MARIAN - University Of Washington
item NICKLES, THERES - Children'S Nutrition Research Center (CNRC)
item OJIAMBO, ROBERT - Moi University
item PIETILAINEN, KIRSI - Helsinki University
item PITSILADIS, YANNIS - The University Of Brighton
item PLANGE-RHULE, JACOB - Kwame Nkrumah University Of Science And Technology
item PLASQUI, GUY - Maastricht University
item PRENTICE, ROSS - University Of Washington
item RABINOVICH, ROBERTO - University Of Edinburgh
item RACETTE, SUSAN - Washington University
item RAICHLEN, DAVID - University Of Southern California
item RAVUSSIN, ERIC - Pennington Biomedical Research Center
item REYNOLDS, REBECCA - University Of Edinburgh
item ROBERTS, SUSAN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item SCHUIT, ALBERTINE - Tilburg University
item SJODIN, ANDERS - Copenhagen University
item STICE, ERIC - Stanford University
item URLACHER, SAMUEL - Baylor University
item VALENTI, GIULIO - Maastricht University
item VAN ETTEN, LUDO - Maastricht University
item VAN MIL, EDGAR - Maastricht University
item WELLS, JONATHAN - Ucl Great Ormond Street Institute Of Child Health
item WILSON, GEORGE - Liverpool John Moores University
item WOOD, BRIAN - University Of California (UCLA)
item YANOVSKI, JACK - National Institutes Of Health (NIH)
item YOSHIDA, TSUKASA - University Of Tsukuba
item ZHANG, XUEYING - University Of Aberdeen
item MURPHY-ALFORD, ALEXA - International Atomic Energy Agency (IAEA)
item LOECHL, CORNELIA - International Atomic Energy Agency (IAEA)
item LUKE, AMY - Loyola University
item ROOD, JENNIFER - Pennington Biomedical Research Center
item SCHOELLER, DALE - University Of Wisconsin
item PONTZER, HERMAN - Duke University
item WONG, WILLIAM - Children'S Nutrition Research Center (CNRC)
item SPEAKMAN, JOHN - University Of Aberdeen

Submitted to: American Journal of Clinical Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/14/2021
Publication Date: 9/3/2021
Citation: Westerterp, K.R., Yamada, Y., Sagayama, H., Ainslie, P.N., Andersen, L.F., Anderson, L.J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E.E., Blanc, S., Bonomi, A.G., Bouten, C.V., Bovet, P., Buchowski, M.D., Butte, N.F., Camps, S.G., Close, G., Cooper, J., Das, S., Cooper, R., Dugas, L., Ekelund, U., Entringer, S., Forrester, T., Fudge, B.W., Goris, A.H., Gurven, M., Hambly, C., El Hamdouchi, A., Hoos, M.B., Hu, S., Joonas, N., Joosen, A.M., Katzmarzyk, P., Kempen, K.P., Kimura, M., Kraus, W.E., Kushner, R., Lambert, E.V., Leonard, W.R., Lessan, N., Martin, C.K., Medin, A.C., Meijer, E.P., Morehen, J.C., Morton, J.P., Neuhouser, M., Nickles, T.A., Ojiambo, R.M., Pietilainen, K.H., Pitsiladis, Y.P., Plange-Rhule, J., Plasqui, G., Prentice, R., Rabinovich, R.A., Racette, S.B., Raichlen, D.A., Ravussin, E., Reynolds, R., Roberts, S., Schuit, A.J., Sjodin, A.M., Stice, E., Urlacher, S.S., Valenti, G., Van Etten, L.M., Van Mil, E.A., Wells, J.C., Wilson, G., Wood, B.M., Yanovski, J., Yoshida, T., Zhang, X., Murphy-Alford, A.J., Loechl, C., Luke, A.M., Rood, J., Schoeller, D.A., Pontzer, H., Wong, W.W., Speakman, J.R. 2021. Physical activity and fat-free mass during growth and in later life. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqab260.
DOI: https://doi.org/10.1093/ajcn/nqab260

Interpretive Summary: Doubly labeled water is a non-invasive method that has become the gold standard measurement of total energy expenditure. When combined with measurements of resting energy expenditure, it can be used to calculate physical activity level as the ratio of total to resting expenditure. This study analyzes a collection of 2000 measurements of physical activity level in individuals aged 3 to 97 years. The results show a strong association of physical activity level with body composition, such that higher levels of physical activity are strongly correlated with lean tissue mass. These results are associational, but may indicate that physical activity level is a crucial determinant of lean tissue mass during the life and into old age.

Technical Abstract: Background. Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass. Objectives. A study is presented of the association between FFM and physical activity in relation to age. Methods. In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3-96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution. Results. PAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males < 18 y old, and 32% and 47% of the variation in FFM in females and males >/= 18 y old, respectively. In participants < 18 y old, mean FM-adjusted FFM was 1.7 kg (95% CI: 0.1, 3.2 kg) and 3.4 kg (95% CI: 1.0, 5.6 kg) higher in a very active participant with PAL = 2.0 than in a sedentary participant with PAL = 1.5, for females and males, respectively. At age 18 y, height and FM-adjusted FFM was 3.6 kg (95% CI: 2.8, 4.4 kg) and 4.4 kg (95% CI: 3.2, 5.7 kg) higher, and at age 80 y 0.7 kg (95% CI: -0.2, 1.7 kg) and 1.0 kg (95% CI: -0.1, 2.1 kg) higher, in a participant with PAL = 2.0 than in a participant with PAL = 1.5, for females and males, respectively. Conclusions. If these associations are causal, they suggest physical activity is a major determinant of body composition as reflected in peak FFM, and that a physically active lifestyle can only partly protect against loss of FFM in aging adults.