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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Foodborne Toxin Detection and Prevention Research » Research » Publications at this Location » Publication #387230

Research Project: Novel Methods for the Mitigation of Human Pathogens and Mycotoxin Contamination of High Value California Specialty Crops

Location: Foodborne Toxin Detection and Prevention Research

Title: Editorial: redox-active molecules as antimicrobials: mechanisms and resistance

item Kim, Jong Heon
item Cheng, Luisa
item LAND, KIRKWOOD - University Of The Pacific
item GRUHLKE, MARTIN - Aachen University

Submitted to: Frontiers in Microbiology
Publication Type: Review Article
Publication Acceptance Date: 8/20/2021
Publication Date: 9/10/2021
Citation: Kim, J., Cheng, L.W., Land, K.M., Gruhlke, M.C. 2021. Editorial: redox-active molecules as antimicrobials: mechanisms and resistance. Frontiers in Microbiology. 12. Article 758750.

Interpretive Summary:

Technical Abstract: The antioxidant system of microbes could be an effective target for pathogen control. Redox-active molecules (natural or synthetic) can function as potent redox-cyclers in microbes, which contributes to the inhibition of pathogen growth by disrupting cellular redox homeostasis or the function of redox-sensitive cellular components. In fungal pathogens, oxidative stress signals are integrated into the upstream mitogen-activated protein kinase (MAPK) systems, which then regulate the downstream response genes countering the stress. Noteworthy, MAPK mutants of fungal pathogens developed resistance to the phenylpyrrole antifungal fludioxonil. Therefore, identification of new, safe redox-active molecules and elucidation of their oxidative mechanisms will further the control of microbial pathogens, especially those resistant to current therapeutic agents.