|Kim, Jong Heon|
|LAND, KIRKWOOD - University Of The Pacific|
|GRUHLKE, MARTIN - Aachen University|
Submitted to: Frontiers in Microbiology
Publication Type: Review Article
Publication Acceptance Date: 8/20/2021
Publication Date: 9/10/2021
Citation: Kim, J., Cheng, L.W., Land, K.M., Gruhlke, M.C. 2021. Editorial: redox-active molecules as antimicrobials: mechanisms and resistance. Frontiers in Microbiology. 12. Article 758750. https://doi.org/10.3389/fmicb.2021.758750.
Technical Abstract: The antioxidant system of microbes could be an effective target for pathogen control. Redox-active molecules (natural or synthetic) can function as potent redox-cyclers in microbes, which contributes to the inhibition of pathogen growth by disrupting cellular redox homeostasis or the function of redox-sensitive cellular components. In fungal pathogens, oxidative stress signals are integrated into the upstream mitogen-activated protein kinase (MAPK) systems, which then regulate the downstream response genes countering the stress. Noteworthy, MAPK mutants of fungal pathogens developed resistance to the phenylpyrrole antifungal fludioxonil. Therefore, identification of new, safe redox-active molecules and elucidation of their oxidative mechanisms will further the control of microbial pathogens, especially those resistant to current therapeutic agents.