|GREENBERG, ANDREW - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY|
|REEVES, ANDREW - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY|
Submitted to: Cell Metabolism
Publication Type: Review Article
Publication Acceptance Date: 4/6/2021
Publication Date: 4/6/2021
Citation: Greenberg, A., Reeves, A. 2021. The good and bad of adipose tissue macrophage exosomes in obesity. Cell Metabolism. 33(4):700-702. https://doi.org/10.1016/j.cmet.2021.03.011.
Technical Abstract: Adipose tissue macrophages regulate adipose tissue inflammation and systemic insulin-glucose homeostasis. In a recent study by Ying et. al. (2021), M2 polarized bone marrow-derived macrophages secreted exosomes containing miR-690 that, when administered to obese mice, improved glucose-insulin homeostasis. miR-690 reduced expression of Nadk which decreased inflammation and improved insulin signaling.