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Research Project: Intervention Strategies to Control Influenza A Virus Infection in Swine

Location: Virus and Prion Research

Title: Swine influenza A viruses and the tangled relationship with humans

item Anderson, Tavis
item CHANG, JENNIFER - Orise Fellow
item ARENDSEE, ZEBULUN - Orise Fellow
item VEKATESH, DIVYA - Royal Veterinary College
item SOUZA, CARINE - Orise Fellow
item KIMBLE, BRIAN - Orise Fellow
item LEWIS, NICOLA - Royal Veterinary College
item DAVIS, C.TODD - Centers For Disease Control And Prevention (CDC) - United States
item Baker, Amy

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 11/15/2019
Publication Date: 1/27/2020
Citation: Anderson, T.K., Chang, J., Arendsee, Z., Vekatesh, D., Souza, C.K., Kimble, B., Lewis, N., Davis, C., Vincent, A.L. 2020. Swine influenza A viruses and the tangled relationship with humans. In:Neumann, G. , Kawaoka, Y., editors. Influenza: The Cutting Edge. Cold Spring Harbor Perspectives in Medicine. Cold Spring Harbor Laboratory Press.10(7):p.a038737.

Interpretive Summary:

Technical Abstract: Influenza A viruses (IAV) are the causative agents of one of the most important viral respiratory diseases in pigs and humans. Human and swine IAV are prone to interspecies transmission, leading to regular incursions from human to pig and vice versa. This bidirectional transmission of IAV has heavily influenced the evolutionary history of IAV in both species. Transmission to pigs of distinct human seasonal lineages, followed by sustained within-host transmission and rapid adaptation and evolution represent a considerable challenge for pig health and production. Consequently, although only subtypes of H1N1, H1N2, and H3N2 are endemic in swine around the world, extensive diversity can be found in the hemagglutinin (HA) and neuraminidase (NA) genes, as well as the remaining 6 genes. The complicated global epidemiology of IAV in swine and the implications for public health and influenza pandemic planning are inextricably entangled, and are reviewed in this chapter.