Location: Virus and Prion ResearchTitle: Ten years after the 2009 H1N1 pandemic – what have we learned about the swine-human interface of influenza?
|CHANG, JENNIFER - Orise Fellow|
|ARENDSEE, ZEBULUN - Orise Fellow|
|VENKATESH, DIVYA - University Of London|
|SOUZA, CARINE - Orise Fellow|
|KIMBLE, BRIAN - Orise Fellow|
|LEWIS, NICOLA - University Of London|
|DAVIS, TODD - Centers For Disease Control And Prevention (CDC) - United States|
Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 10/22/2019
Publication Date: 11/3/2019
Citation: Vincent, A.L., Anderson, T.K., Chang, J., Arendsee, Z.W., Venkatesh, D., Souza, C.K., Kimble, B.J., Lewis, N.S., Davis, T. 2019. Ten years after the 2009 H1N1 pandemic – what have we learned about the swine-human interface of influenza? [abstract]. The 100th Annual Conference of Research Workers in Animal Diseases (CRWAD),2019t. Abstract No. 103.
Technical Abstract: Influenza A viruses (IAV) are the causative agents of one of the most important viral respiratory diseases in pigs and humans. Human and swine IAV are prone to interspecies transmission, leading to regular incursions from human to pig and vice versa. This bidirectional transmission of IAV has heavily influenced the evolutionary history of IAV in both species. Interspecies transmission of distinct human seasonal lineages, adaptation followed by sustained and intense within-host transmission, virus migration through live pig transport and trade, and rapid evolution represent a considerable challenge for pig health and production. Consequently, although only subtypes of H1N1, H1N2, and H3N2 are endemic in swine around the world, considerable genetic and antigenic diversity can be found in the hemagglutinin (HA) and neuraminidase (NA) genes, as well as the remaining 6 genes. The risk of this pattern to the human population of regular human seasonal IAV incursion and IAV evolution in swine was brought to the forefront during the 2009 H1N1 human pandemic. The complicated global epidemiology of IAV in swine and the implications for public health and influenza pandemic planning are inextricably entangled and will be reviewed in the presentation.