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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #367480
Research Project: Intervention Strategies to Control Influenza A Virus Infection in Swine

Location: Virus and Prion Research

Title: PhyloVirus: Inferring virus reassortment and recombination, and a visualization tool for phylogenetic networks

Author
item MUBARAKI, F - Iowa State University
item Anderson, Tavis
item MARKIN, A - Iowa State University
item MILLER, L - Iowa State University
item EULENSTEIN, O - Iowa State University

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 9/9/2019
Publication Date: 11/4/2019
Citation: Mubaraki, F., Anderson, T.K., Markin, A., Miller, L., Eulenstein, O. 2019. PhyloVirus: Inferring virus reassortment and recombination, and a visualization tool for phylogenetic networks [abstract].The 100th Annual Conference of Research Workers in Animal Diseases.Abstract No. 182.

Interpretive Summary:

Technical Abstract: RNA virus diversity is the result of mutation, recombination, and reassortment. Traditional virus evolution studies rely on single-gene phylogenetic trees that do not account for all these processes. Phylogenetic network algorithms can do so but are hampered by computational limitations. We introduce an efficient software package with a graphical user interface called PhyloVirus that constructs and allows visualization of phylogenetic trees, median trees, and networks. We apply our software to swine influenza A virus (IAV), quantifying reassortment events in the evolution of H3N2 viruses and identify novel reassorted viruses.