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Research Project: Intervention Strategies to Control Influenza A Virus Infection in Swine

Location: Virus and Prion Research

Title: Evolutionary diversification of clade 1A.3.3.3 H1 swine influenza A viruses and zoonotic risk in the United States

Author
item Anderson, Tavis
item HEWITT, KELLY - Oak Ridge Institute For Science And Education (ORISE)
item CHANG, JENNIFER - Oak Ridge Institute For Science And Education (ORISE)
item ZELLER, MICHAEL - Iowa State University
item VENKATESH, DIVYA - University Of London
item LEWIS, NICOLA - University Of London
item Vincent, Amy

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/18/2019
Publication Date: 11/4/2019
Citation: Anderson, T.K., Hewitt, K.F., Chang, J., Zeller, M.A., Venkatesh, D., Lewis, N.S., Vincent, A.L. 2019. Evolutionary diversification of clade 1A.3.3.3 H1 swine influenza A viruses and zoonotic risk in the United States [abstract]. Conference of Research Workers in Animal Diseases. Abstract No. 181.

Interpretive Summary:

Technical Abstract: Objective: Increasing diversity of influenza A virus (IAV) circulating in swine can indicate a need for animal and public health intervention efforts. In 2015, two human variant cases were detected in the United States and identified as 1A.3.3.3 (gamma) clade H1N1 swine-origin viruses. These transmission episodes underscored the genetic diversity of this H1 clade previously observed to be expanding. We hypothesized that evolutionary selection on the HA gene resulted in antigenic drift in swine and potentially increased the risk for interspecies transmission.