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Title: Beverage consumption and longitudinal changes in lipid concentrations and incident dyslipidemia in U.S. adults: the Framingham Heart Study

Author
item HASLAM, DANIELLE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item PELOSO, GINA - Boston University
item HERMAN, MARK - Duke University
item DUPUIS, JOSEE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item LICHTENSTEIN, ALICE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item SMITH, CAREN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item MCKEOWN, NICOLA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Current Developments in Nutrition
Publication Type: Abstract Only
Publication Acceptance Date: 4/25/2019
Publication Date: 6/13/2019
Citation: Haslam, D.E., Peloso, G.M., Herman, M.A., Dupuis, J., Lichtenstein, A.H., Smith, C.E., McKeown, N.M. 2019. Beverage consumption and longitudinal changes in lipid concentrations and incident dyslipidemia in U.S. adults: the Framingham Heart Study [abstract]. Current Developments in Nutrition. 3(Suppl_1). Abstract No. P18-017-19. https://doi.org/10.1093/cdn/nzz039.P18-017-19.
DOI: https://doi.org/10.1093/cdn/nzz039.P18-017-19

Interpretive Summary:

Technical Abstract: Objectives: Limited data are available on the prospective relationship between beverage consumption and plasma lipid and lipoprotein concentrations in population-based studies. Two major sources of sugar in the US diet are sugar-sweetened beverages (SSB; sodas and fruit drinks) and 100% fruit juices (FJ). Low-calorie sweetened beverages (LCSB) are common replacements for SSB and FJ. Methods: Fasting plasma triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) concentrations were measured at up to 5 exams in Framingham Heart Study offspring and up to 2 exams in generation 3 cohorts (1998-2005; N=6,730). Consumption of SSB, FJ, and LCSB were estimated from food frequency questionnaires and intakes were categorized. Mixed-effect linear regression models were used to examine changes in lipid concentrations, and Cox proportional hazard models were used to estimate hazard ratios (HR) for incident dyslipidemia, adjusting for potential confounding factors. Results were statistically significant at a Bonferroni-corrected p-value < 0.017 (0.05/3 outcomes). Results: In multivariate-adjusted models, SSB intake was associated with smaller mean 4-year changes in HDL-C [high (>1 serving/day) vs. low intake category (<1 serving/month) (H vs. L): B +/- SE: -1.0 +/- 0.3 mg/dl, p trend < 0.0001] and greater mean 4-year changes in TG concentrations (H vs. L: B +/- SE: 5.7 +/- 2.1 mg/dl, p trend = 0.0003), along with a higher incidence of low HDL-C [H vs. L HR (95% CI): 1.64 (1.06-2.54), p for trend = 0.01] and high TG concentrations [H vs. L HR (95% CI): 1.46 (1.05-2.03); p trend = 0.009]. LCSB intake was associated with a higher incidence of low HDL-C [H vs. L HR (95% CI): 1.38 (1.02-1.86), p trend = 0.01] and high LDL-C concentrations [H vs. L HR (95% CI): 1.19 (1.00-1.41); p trend = 0.01]. No other significant associations between beverage consumption and lipid concentrations or incident dyslipidemia were observed. Conclusions: SSB intake was associated with changes in HDL-C and TG concentrations and higher risk of dyslipidemia, suggesting that SSB consumption should be limited. LCSB intake was not associated with changes in lipid concentrations, but higher intake was associated with risk of dyslipidemia. Thus, limiting LCSB intake is recommended based on these study findings.