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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #363284

Research Project: Genomics, Nutrition, and Health

Location: Jean Mayer Human Nutrition Research Center On Aging

Title: Development of a genetic score to predict an increase in HDL cholesterol concentration after a dietary intervention in adults with metabolic syndrome

Author
item GUEVARA-CRUZ, MARTHA - SALVADOR ZUBIRAN NATIONAL INSTITUTE OF MEDICAL SCIENCES AND NUTRITION
item MEDINA-VERA, ISABEL - SALVADOR ZUBIRAN NATIONAL INSTITUTE OF MEDICAL SCIENCES AND NUTRITION
item FLORES-LOPEZ, ADRIAN - SALVADOR ZUBIRAN NATIONAL INSTITUTE OF MEDICAL SCIENCES AND NUTRITION
item AGUILAR-LOPEZ, MIRIAM - SALVADOR ZUBIRAN NATIONAL INSTITUTE OF MEDICAL SCIENCES AND NUTRITION
item SMITH, CAREN - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY
item Parnell, Laurence
item LEE, YU-CHI - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY
item Lai, Chao Qiang
item TOVAR, ARMANDO - SALVADOR ZUBIRAN NATIONAL INSTITUTE OF MEDICAL SCIENCES AND NUTRITION
item ORDOVAS, JOSE - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY
item TORRES, NIMBE - SALVADOR ZUBIRAN NATIONAL INSTITUTE OF MEDICAL SCIENCES AND NUTRITION

Submitted to: Journal of Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 3/8/2019
Publication Date: 5/9/2019
Citation: Guevara-Cruz, M., Medina-Vera, I., Flores-Lopez, A., Aguilar-Lopez, M., Smith, C.E., Parnell, L.D., Lee, Y., Lai, C., Tovar, A.R., Ordovas, J.M., Torres, N. 2019. Development of a genetic score to predict an increase in HDL cholesterol concentration after a dietary intervention in adults with metabolic syndrome. Journal of Nutrition. https://doi.org/10.1093/jn/nxz060.
DOI: https://doi.org/10.1093/jn/nxz060

Interpretive Summary: Personalized nutrition is based on the concept that individuals with different genetic backgrounds could respond differently to the same diet/food based on their genetic makeup. To test this notion, the investigators recruited 67 Mexican men and women at high risk of cardiovascular disease to participate in a dietary intervention study consisting of low fat and calorie reduced diet for 2.5 months. A genetic score (GS) that was calculated for each participant was based on gene variants that are associated with the response of the good-cholesterol (HDL-Cholesterol) levels to dietary interventions. The results of this study show that individuals with a low GS had more significant benefit from the diet, with increases in HDL-cholesterol levels, than those with a high GS that experienced decreases in HDL-Cholesterol levels. Moreover, these findings were replicated in an independent group of people, strengthening the study. These results provides further evidence that individuals with different levels of genetic risk respond differently to the same type of diet and supports the advantages of personalized nutrition to improve dietary prevention and treatment of disease.

Technical Abstract: Background: Dietary intervention (DI) in individuals with metabolic syndrome (MetS) is the first strategy to attenuate some of the associated metabolic abnormalities, including low HDL-cholesterol (HDL-C). There is no biomarker that can identify individuals who respond to a DI with an increase in HDL-C. Objective: The aim of this study was to assess the predictive power of a genetic predisposition score (GPS) in Mexican adults with MetS to identify HDL-C responders to DI. Methods: This study followed a prospective cohort design. Sixty seven Mexican adults aged 20-60 y (21% men) with BMI >/= 25 and