Location: Virus and Prion ResearchTitle: A brief introduction to influenza A virus in swine
Submitted to: Animal Influenza Virus
Publication Type: Book / Chapter
Publication Acceptance Date: 3/4/2019
Publication Date: 3/14/2020
Citation: Vincent, A.L., Anderson, T.K., Lager, K.M. 2020. A brief introduction to influenza A virus in swine. Animal Influenza Virus. p. 249-271. https://doi.org/10.1007/978-1-0716-0346-8_18.
Technical Abstract: Influenza A viruses (IAV) of the Orthomyxoviridae virus family cause one of the most important respiratory diseases in pigs and humans. Repeated outbreaks and rapid spread of genetically and antigenically distinct IAVs represent a considerable challenge for animal production and public health. Bidirection transmission of IAV between pigs and people has altered the evolutionary dynamics of IAV and a “One Health” approach is required to ameliorate morbidity and mortality in both hosts and improve control strategies. Although only subtypes of H1N1, H1N2, and H3N2 are endemic in swine around the world, considerable diversity can be found not only in the hemagglutinin (HA) and neuraminidase (NA) genes, but in the remaining 6 genes as well. Human and swine IAV have demonstrated a particular propensity for interspecies transmission, leading to regular and sometimes sustained, incursions from man to pig and vice versa. The diversity of IAV in swine remains one of the critical challenges in diagnosis and control of this important pathogen for swine health, and in turn contributes to a significant public health risk.