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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #355571

Research Project: Intervention Strategies to Control Influenza A Virus Infection in Swine

Location: Virus and Prion Research

Title: Complete genome sequences of two novel human-like H3N2 influenza A viruses A/swine/Oklahoma/65980/2017(H3N2) and A/swine/Oklahoma/65260/2017(H3N2) detected in swine in the United States

Author
item ZELLER, MICHAEL - Iowa State University
item LI, GANWU - Iowa State University
item HARMON, KAREN - Iowa State University
item ZHANG, JIANQIANG - Iowa State University
item Vincent, Amy
item Anderson, Tavis
item GAUGER, PHILLIP - Iowa State University

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/24/2018
Publication Date: 11/21/2018
Citation: Zeller, M.A., Li, G., Harmon, K.M., Zhang, J., Vincent, A.L., Anderson, T.K., Gauger, P.C. 2018. Complete genome sequences of two novel human-like H3N2 influenza A viruses A/swine/Oklahoma/65980/2017(H3N2) and A/swine/Oklahoma/65260/2017(H3N2) detected in swine in the United States. Microbiology Resource Announcements. 7(20):e01203-18. https://doi.org/10.1128/MRA.01203-18.
DOI: https://doi.org/10.1128/MRA.01203-18

Interpretive Summary: Influenza A virus (IAV) is an RNA virus that infects birds and mammals and can rapidly change to escape immunity or infect different hosts. IAV strains can be shared between humans and pigs and is a cause of respiratory disease in both. Currently, there are three IAV subtypes circulating in North American swine, H1N1, H1N2, and H3N2. Spillover of human seasonal IAV into swine occurs sporadically, resulting in the emergence of novel strains and increased genetic diversity of IAV maintained in swine. Here we describe the detection of two novel swine IAV in 2017 containing human seasonal influenza gene segments. Two novel human-like H3N2 influenza A viruses were isolated from porcine samples and whole genome sequences are reported. This report provides evidence of a recent human-to-swine transmission of a human seasonal H3N2 and underscores the importance of preventing human IAV transmission to swine in production facilities.

Technical Abstract: Two novel human-like H3N2 influenza A viruses, A/swine/Oklahoma/65980/2017(H3N2) (MG720213-MG720220) and A/swine/Oklahoma/65260/2017(H3N2) (MG720221-MG720228), were isolated from porcine samples submitted to the Iowa State University Veterinary Diagnostic Laboratory in the United States.