Location: Virus and Prion ResearchTitle: Complete genome sequences of two novel human-like H3N2 influenza A viruses A/swine/Oklahoma/65980/2017(H3N2) and A/swine/Oklahoma/65260/2017(H3N2) detected in swine in the United States
|ZELLER, MICHAEL - Iowa State University|
|LI, GANWU - Iowa State University|
|HARMON, KAREN - Iowa State University|
|ZHANG, JIANQIANG - Iowa State University|
|GAUGER, PHILLIP - Iowa State University|
Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/24/2018
Publication Date: 11/21/2018
Citation: Zeller, M.A., Li, G., Harmon, K.M., Zhang, J., Vincent, A.L., Anderson, T.K., Gauger, P.C. 2018. Complete genome sequences of two novel human-like H3N2 influenza A viruses A/swine/Oklahoma/65980/2017(H3N2) and A/swine/Oklahoma/65260/2017(H3N2) detected in swine in the United States. Microbiology Resource Announcements. 7(20):e01203-18. https://doi.org/10.1128/MRA.01203-18.
Interpretive Summary: Influenza A virus (IAV) is an RNA virus that infects birds and mammals and can rapidly change to escape immunity or infect different hosts. IAV strains can be shared between humans and pigs and is a cause of respiratory disease in both. Currently, there are three IAV subtypes circulating in North American swine, H1N1, H1N2, and H3N2. Spillover of human seasonal IAV into swine occurs sporadically, resulting in the emergence of novel strains and increased genetic diversity of IAV maintained in swine. Here we describe the detection of two novel swine IAV in 2017 containing human seasonal influenza gene segments. Two novel human-like H3N2 influenza A viruses were isolated from porcine samples and whole genome sequences are reported. This report provides evidence of a recent human-to-swine transmission of a human seasonal H3N2 and underscores the importance of preventing human IAV transmission to swine in production facilities.
Technical Abstract: Two novel human-like H3N2 influenza A viruses, A/swine/Oklahoma/65980/2017(H3N2) (MG720213-MG720220) and A/swine/Oklahoma/65260/2017(H3N2) (MG720221-MG720228), were isolated from porcine samples submitted to the Iowa State University Veterinary Diagnostic Laboratory in the United States.