|Sharma, Poonam - Orise Fellow|
|Gupta, Sushim - Orise Fellow|
|Adenipekun, Eyitayo - University Of Lagos|
|Iwalokun, Bamidele - Olabisi Onabanjo University|
|Oyedeji, Kolawole - University Of Lagos|
|Oluwadun, Afolabi - Olabisi Onabanjo University|
|Ramadan, Hazem - Mansoura University|
Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/1/2017
Publication Date: 10/5/2017
Citation: Sharma, P., Gupta, S., Adenipekun, E., Barrett, J.B., Hiott, L.M., Woodley, T.A., Iwalokun, B., Oyedeji, K., Oluwadun, A., Ramadan, H., Frye, J.G., Jackson, C.R. 2017. Draft genome sequence analysis of multidrug-resistant Escherichia coli strains isolated in 2013 from humans and chickens in Nigeria. Genome Announcements. 5(40):e01073-17. doi:10.1128/genomeA.01073-17.
DOI: https://doi.org/10.1128/genomeA.01073-17 Interpretive Summary: Escherichia coli is a common commensal of the intestinal tract of humans and animals, but can also be an opportunist pathogen associated with illnesses caused by food-producing animals. In order to effectively treat these infections, it is important to understand the mechanisms of resistance in E. coli. In this study, nine multidrug-resistant E. coli isolated from humans and chicken carcass from Lagos, Nigeria in 2013 were sequenced. Multiple extended-spectrum beta-lactamase genes were identified in these isolates. The isolates also harbored genes conferring resistance to aminoglycosides, tetracycline, trimethoprim, sulfonamides, fluoroquinolones, and chloramphenicol consistent with their reported phenotypes. Monitoring antimicrobial resistance in under-funded countries is necessary to ensure continued effectiveness of antimicrobials. This information is useful for policy makers and scientists as they develop prevention and control strategies for combating antimicrobial resistance.
Technical Abstract: Here, we present the draft genome sequences of nine multidrug-resistant Escherichia coli isolated from humans (n=6) and chicken carcass (n=3) from Lagos, Nigeria in 2013. Multiple extended-spectrum beta-lactamase (ESBL) genes were identified in these isolates.