|ROWAN, SHELDON - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
|TAYLOR, ALLEN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University|
Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 9/1/2015
Publication Date: 10/2/2015
Citation: Rowan, S., Taylor, A. 2015. Gene-diet interactions in age-related macular degeneration. In: Bowes Rickman, C., editor. Advances in Experimental Medicine and Biology: Reginal Degenerative Diseases. Switzerland: Springer International. p.95-101. doi: 10.1007/978-3-319-17121-0_14
Technical Abstract: Age-related macular degeneration (AMD) is a prevalent blinding disease, accounting for roughly 50% of blindness in developed nations. Very significant advances have been made in terms of discovering genetic susceptibilities to AMD as well as dietary risk factors. To date, nutritional supplementation is the only available treatment option for the dry form of the disease known to slow progression of AMD. Despite an excellent understanding of genes and nutrition in AMD, there is remarkably little known about gene-diet interactions that may identify efficacious approaches to treat individuals. This review will summarize our current understanding of gene-diet interactions in AMD with a focus on animal models and human epidemiological studies.