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ARS Home » Southeast Area » Miami, Florida » Subtropical Horticulture Research » Research » Publications at this Location » Publication #339173

Research Project: Methyl Bromide Replacement: Mitigation of the Invasive Pest Threat from the American Tropics and Subtropics

Location: Subtropical Horticulture Research

Title: Comparative Study of Three Achillea Essential Oils from Eastern Part of Turkey and their Biological Activities.

Author
item Demirci, Betul - Anadolu Universtiy
item Kemal Husnu, Can Baser - Near East University
item Aytac, Zeki - Gazi University
item Khan, Shabana - University Of Mississippi
item Jacob, Melissa - University Of Mississippi
item Tabanca, Nurhayat

Submitted to: Records of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 7/26/2017
Publication Date: 7/26/2017
Citation: Demirci, B., Kemal Husnu, C., Aytac, Z., Khan, S.I., Jacob, M.R., Tabanca, N. 2017. Comparative Study of Three Achillea Essential Oils from Eastern Part of Turkey and their Biological Activities.. Records of Natural Products. DOI: http://doi.org/10.25135/rnp.09.17.03.019

Interpretive Summary: Achillea L. is a large genus belonging to the family Asteraceae and Achillea species comprise an important biological resource in folk medicine to treat various diseases and several of them are used for their pharmaceutical, cosmetic, and fragrance properties. Biological activities of various Achillea species include angiogenic, anxiolytic, antifungal, antibacterial, anti-inflammatory, antimicrobial, genotoxicity, hepatoptotective, herbicidal, insecticidal, antioxidant and antiradical. In continuation of our studies on screening EOs from medicinal plants growing wild, we investigated three Achillea species (A. filipendulina Lam.,, A. tenuifolia Lam., and A. magnifica Hiemerl ex Hub.-Mor.) from Turkey and their antimicrobial and antimalarial activities.

Technical Abstract: Essential oils obtained by hydrodistillation were analyzed both by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The main constituents found in Achillea oil were as follows: A. filipendulina Lam.: 43.8% santolina alcohol, 14.5% 1,8-cineole and 12.5% cis-chrysanthenyl acetate; A. magnifica Hiemerl ex Hub.-Mor.: 27.5% linalool, 5.8% spathulenol, 5.5% terpinen-4-ol, 4.7% a-terpineol and 4.7% ß-eudesmol; A. tenuifolia Lam.: 12.4% artemisia ketone, 9.9% p-cymene, 7.1% camphor, 5.9% terpinen-4-ol, 4.7% caryophyllene oxide and 4.5% a-pinene. Furthermore, the Achillea essential oils were evaluated for antimalarial and antimicrobial activities. Achillea oils showed no antibacterial activity against human pathogenic bacteria up to a concentration of 200 'g/mL. A. tenuifolia and A. magnifica oils demonstrated mild antifungal activity against Cryptococcus neoformans (IC50= 45, 20 and 15 'g/mL, respectively). A. magnifica and A. filipendulina oils showed strong antimalarial activity against both chloroquine sensitive D6 (IC50= 1.2 and 0.68 'g/mL) and chloroquine resistant W2 (IC50= 1.1 and 0.9 'g/mL) strains of Plasmodium falciparum without any cytotoxicity to mammalian cells.