Author
FRETTS, AMANDA - University Of Washington | |
FOLLIS, JACK - University Of St Thomas | |
NETTLETON, JENNIFER - University Of Texas Health Science Center | |
LEMAITRE, ROZENN - University Of Washington | |
NGWA, JULIUS - Boston University School Of Public Health | |
WOJCZYNSKI, MARY - Washington University | |
KALAFATI, IOANNA - Harokopio University Of Athens | |
VARGA, TIBOR - Lund University | |
FRAZIER-WOOD, ALEXIS - Children'S Nutrition Research Center (CNRC) | |
HOUSTON, DENISE - Wake Forest School Of Medicine | |
LAHTI, JARI - University Of Helsinki | |
ULRIKA, ERICSON - Lund University | |
VAN DEN HOOVEN, EDITH - Erasmus University | |
MIKKILA, VERA - University Of Helsinki | |
KIEFTE-DE JONG, JESSICA - Erasmus Medical Center | |
MOZAFFARIAN, DARIUSH - Tufts University | |
RICE, KENNETH - University Of Washington | |
RENSTROM, FRIDA - Lund University | |
NORTH, KARI - University Of North Carolina | |
MCKEOWN, NICOLA - Tufts University | |
FEITOSA, MARY - Washington University | |
KANONI, STAVROULA - Queen Mary University Of London | |
SMITH, CAREN - Tufts University | |
GARCIA, MELISSA - National Institute For Health And Welfare (HELSINKI) | |
TIAINEN, ANNA-MAIJA - National Institute For Health And Welfare (HELSINKI) | |
SONESTEDT, EMILY - Lund University | |
MANICHAIKUL, ANI - University Of Virginia | |
VAN ROOIJ, FRANK - Leiden University | |
DIMITRIOU, MARIA - Harokopio University Of Athens | |
RAITAKARI, OLLI - University Of Turku | |
PANKOW, JAMES - University Of Minnesota | |
DJOUSSE, LUC - Brigham & Women'S Hospital | |
PROVINCE, MICHAEL - Washington University | |
HU, FRANK - Harvard School Of Public Health | |
LAI, CHAO-QIANG - Tufts University | |
KELLER, MARGAUX - National Institutes Of Health (NIH) | |
PERALA, MIA-MARIA - National Institute For Health And Welfare (HELSINKI) | |
ROTTER, JEROME - Harbor-Ucla Medical Center | |
HOFMAN, ALBERT - University Of Turku | |
GRAFF, MISA - University Of North Carolina | |
KAHONEN, MIKA - University Of Tampere Medical School | |
MUKAMAL, KENNETH - Beth Israel Deaconess Medical Center | |
JOHANSSON, INGEGERD - University Of Umea | |
ORDOVAS, JOSE - Tufts University | |
LIU, YONGMEI - Wake Forest School Of Medicine | |
MANNISTO, SATU - National Institute For Health And Welfare (HELSINKI) | |
UITTERLINDEN, ANDRE - University Of Helsinki | |
DELOUKAS, PANOS - Queen Mary University Of London | |
SEPPALA, ILKKA - University Of Tampere Medical School | |
PSATY, BRUCE - University Of Washington | |
CUPPLES, ADRIENNE - Boston University | |
BORECKI, INGRID - Washington University | |
FRANKS, PAUL - University Of Umea | |
ARNETT, DONNA - University Of Alabama | |
NALLS, MIKE - National Institutes Of Health (NIH) | |
ERIKSSON, JOHAN - University Of Helsinki | |
ORHO-MELANDER, MARJU - Lund University | |
FRANCO, OSCAR - Erasmus University | |
LEHTIMAKI, TERHO - University Of Tampere Medical School | |
DEDOUSSIS, GEORGE - Harokopio University Of Athens | |
MEIGS, JAMES - Massachusetts General Hospital | |
SISCOVICK, DAVID - University Of Washington |
Submitted to: The American Journal of Clinical Nutrition
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 8/5/2015 Publication Date: 9/9/2015 Citation: Fretts, A.M., Follis, J.L., Nettleton, J.A., Lemaitre, R., Ngwa, J.S., Wojczynski, M.K., Kalafati, I.P., Varga, T.V., Frazier-Wood, A.C., Houston, D.K., Lahti, J., Ulrika, E., Van Den Hooven, E.H., Mikkila, V., Kiefte-De Jong, J.C., Mozaffarian, D., Rice, K., Renstrom, F., North, K.E., McKeown, N.M., Feitosa, M.F., Kanoni, S., Smith, C.E., Garcia, M.E., Tiainen, A., Sonestedt, E., Manichaikul, A., Van Rooij, F.J., Dimitriou, M., Raitakari, O., Pankow, J.S., Djousse, L., Province, M.A., Hu, F.B., Lai, C., Keller, M.F., Perala, M., Rotter, J.I., Hofman, A., Graff, M., Kahonen, M., Mukamal, K., Johansson, I., Ordovas, J.M., Liu, Y., Mannisto, S., Uitterlinden, A.G., Deloukas, P., Seppala, I., Psaty, B.M., Cupples, A.L., Borecki, I.B., Franks, P.W., Arnett, D.K., Nalls, M.A., Eriksson, J.G., Orho-Melander, M., Franco, O.H., Lehtimaki, T., Dedoussis, G.V., Meigs, J.B., Siscovick, D.S. 2015. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. American Journal of Clinical Nutrition. 102:1266-1278. Interpretive Summary: Meat intake, especially that of red meat, is associated with diabetes-related traits such as fasting glucose and insulin. Recently, in the field of nutrition, there has been the notion that the association of any dietary intake with health outcomes might be dependent on genotype. However, this has not been studied in relation to meat intake and diabetes. We found that processed meat was associated with higher fasting glucose, and unprocessed red meat was associated with both higher fasting glucose and fasting insulin concentrations. These were not modified by genetic loci known to influence fasting glucose or insulin resistance. This information will help us prevent diabetes, for example, we know that overall body mass index may be a more important intervention targets that meat intake. Technical Abstract: Recent studies suggest that meat intake is associated with diabetes-related phenotypes. However, whether the associations of meat intake and glucose and insulin homeostasis are modified by genes related to glucose and insulin is unknown. We investigated the associations of meat intake and the interaction of meat with genotype on fasting glucose and insulin concentrations in Caucasians free of diabetes mellitus. Fourteen studies that are part of the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium participated in the analysis. Data were provided for up to 50,345 participants. Using linear regression within studies and a fixed-effects meta-analysis across studies, we examined 1) the associations of processed meat and unprocessed red meat intake with fasting glucose and insulin concentrations; and 2) the interactions of processed meat and unprocessed red meat with genetic risk score related to fasting glucose or insulin resistance on fasting glucose and insulin concentrations. Processed meat was associated with higher fasting glucose, and unprocessed red meat was associated with both higher fasting glucose and fasting insulin concentrations after adjustment for potential confounders [not including body mass index (BMI)]. For every additional 50-g serving of processed meat per day, fasting glucose was 0.021 mmol/L (95% CI: 0.011, 0.030 mmol/L) higher. Every additional 100-g serving of unprocessed red meat per day was associated with a 0.037-mmol/L (95% CI: 0.023, 0.051-mmol/L) higher fasting glucose concentration and a 0.049-ln-pmol/L (95% CI: 0.035, 0.063-ln-pmol/L) higher fasting insulin concentration. After additional adjustment for BMI, observed associations were attenuated and no longer statistically significant. The association of processed meat and fasting insulin did not reach statistical significance after correction for multiple comparisons. Observed associations were not modified by genetic loci known to influence fasting glucose or insulin resistance. The association of higher fasting glucose and insulin concentrations with meat consumption was not modified by an index of glucose- and insulin-related single-nucleotide polymorphisms. |