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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #334178

Title: The genetic diversity of contemporary swine influenza A viruses in the United States

item WALIA, RASNA - Orise Fellow
item Anderson, Tavis
item Baker, Amy

Submitted to: Popular Publication
Publication Type: Popular Publication
Publication Acceptance Date: 7/26/2016
Publication Date: 8/9/2016
Citation: Walia, R.R., Anderson, T.K., Vincent, A.L. 2016. The genetic diversity of contemporary swine influenza A viruses in the United States. Available:

Interpretive Summary:

Technical Abstract: Introduction: Influenza A virus (IAV) is one of the most important respiratory pathogens of swine. It impacts mortality and causes significant financial losses through decreased production and the costs associated with vaccination and treatment. Further, due to the susceptibility of swine to transient infection with IAV from different species, namely humans, novel reassorted viruses may emerge that have implications for public health. Consequently, understanding the genetic diversity of circulating viruses in swine can identify novel viral lineages, and provide criteria for informing and improving intervention strategies. Conclusion: The genetic diversity of swine IAV is a complex issue at regional and especially at global levels. In the United States, there are 17 genetic clades that have emerged and persisted following spillover events from non-swine (namely human) hosts and subsequent ecological and evolutionary processes. The temporal and spatial description of the genetics of contemporary swine IAV can be used to inform studies on antigenic evolution and diversity. Together these data, and with the implementation of appropriate vaccination platforms, provide fundamental data for use in the selection of vaccine strains and informs risk management policies for agricultural and public health.