Location: Children's Nutrition Research CenterTitle: Interrelationships between glutamine and citrulline metabolism
|MARINI, JUAN - Children'S Nutrition Research Center (CNRC)|
Submitted to: Current Opinion in Clinical Nutrition and Metabolic Care
Publication Type: Review Article
Publication Acceptance Date: 9/18/2015
Publication Date: 1/1/2016
Citation: Marini, J.C. 2016. Interrelationships between glutamine and citrulline metabolism. Current Opinion in Clinical Nutrition and Metabolic Care. 19(1):62-66.
Technical Abstract: This article analyzes the contribution of glutamine to the synthesis of citrulline and reviews the evidence that glutamine supplementation increases citrulline production. Glutamine supplementation has been proposed in the treatment of critically ill patients; however, a recent large multicenter randomized controlled trial resulted in increased mortality in the glutamine-supplemented group. Within this context, defining the contribution of glutamine to the production of citrulline, and thus to de-novo arginine synthesis, has become a pressing issue. The beneficial effects of glutamine supplementation may be partially mediated by the effects of glutamine on citrulline synthesis by the gut and the de-novo synthesis of arginine by the kidney and other tissues. Although there is no strong evidence to support that glutamine is a major precursor for citrulline synthesis in humans, glutamine has the potential to increase overall gut function and in this way increase citrulline production.