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Research Project: Pediatric Clinical Nutrition

Location: Children's Nutrition Research Center

Title: Extending supplementary feeding for children younger than 5 years with moderate acute malnutrition leads to lower relapse rates

Author
item Trehan, Indi - WASHINGTON UNIVERSITY
item Banerjee, Somalee - WASHINGTON UNIVERSITY
item Murray, Ellen - WASHINGTON UNIVERSITY
item Ryan, Kelsey - WASHINGTON UNIVERSITY
item Thakwalakwa, Chrissie - UNIVERSITY OF MALAWI
item Maleta, Kenneth - UNIVERSITY OF MALAWI
item Manary, Mark - CHILDREN'S NUTRITION RESEARCH CENTER (CNRC)

Submitted to: Journal of Pediatric Gastroenterology and Nutrition
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/13/2014
Publication Date: 4/1/2015
Citation: Trehan, I., Banerjee, S., Murray, E., Ryan, K.N., Thakwalakwa, C., Maleta, K.M., Manary, M.J. 2015. Extending supplementary feeding for children younger than 5 years with moderate acute malnutrition leads to lower relapse rates. Journal of Pediatric Gastroenterology and Nutrition. 60(4):544-549.

Interpretive Summary: There are high relapse and death rates in the year following recovery among children with moderate malnutrition. A group of children recovering from moderate malnutrition were given supplementary food for 12 weeks, rather than just until recovery, which is typically after 3 weeks. The rate of relapse decreased from 35% to 25% with the additional supplementary food.

Technical Abstract: Children with moderate acute malnutrition (MAM) have a high rate of relapse and death in the year following recovery. In this pilot study, we evaluate the long-term benefits of an extended course of nutritional therapy for children with MAM. Rural Malawian children 6 to 59 months old with MAM, defined as a weight-for-height z score (WHZ) between -2 and -3, were provided supplementary feeding for a fixed duration of 12 weeks. The children were then studied for 12 months to assess long-term nutritional status, and compared with children initially treated only until they first reached WHZ>-2. Compared with children treated until they reached WHZ>-2, children treated for 12 weeks were more likely to remain well nourished (71% vs 63%, P=0.0015) and maintain more normal anthropometric indices during 12 months of follow-up; there was also a trend towards lower rates of severe acute malnutrition (7% vs 10%, P=0.067) and death (2% vs 4%, P=0.082). Regression modeling showed that mid-upper arm circumference and WHZ at the end of supplementary feeding were the most important factors in predicting which children remained well nourished (P<0.001 for each). The duration of supplementary feeding for children with MAM may not be as important as their anthropometry in terms of remaining well nourished after initial recovery. The presently accepted recovery criteria of WHZ of -2 may be insufficient for ensuring long-term nutritional health; consideration should be given to setting higher recovery criteria.