|Poulose, Shibu - JEAN MAYER HUMAN NUTRITION RESEARCH CENTER ON AGING AT TUFTS UNIVERSITY|
Submitted to: Neurochemistry International
Publication Type: Review Article
Publication Acceptance Date: 7/22/2015
Publication Date: 9/27/2015
Citation: Poulose, S.M., Thangthaeng, N., Miller, M.G., Shukitt Hale, B. 2015. Effects of pterostilbene and resveratrol on brain and behavior. Neurochemistry International. 89:227-233.
Technical Abstract: Age is the greatest universal risk factor for neurodegenerative diseases. During aging, these conditions progress from minor loss of function to major disruptions in daily life, loss of independence and ultimately death. Because approximately 25% of the world population is expected to be older than age 65 by 2050, and no treatments exist to halt or reverse ongoing neurodegeneration, the need for effective prevention strategies is more pressing than ever before. A growing body of research supports the role of diet, particularly diets rich in bioactive phytochemical compounds, in healthy aging. Recently, stilbenes such as resveratrol (3, 5, 4’-trans-trihydroxystilbene) and its analogue, pterostilbene, have gained a significant amount of attention for their potent antioxidant, anti-inflammatory, and anticarcinogenic properties. However, evidence for the beneficial effects of stilbenes on cerebral function are just beginning to emerge. In this review, we summarize the current knowledge on the role of resveratrol and pterostilbene in improving brain health during aging, with specific focus on antioxidant and anti-inflammatory signaling and behavioral outcomes.