Page Banner

United States Department of Agriculture

Agricultural Research Service

Research Project: Molecular, Cellular, and Regulatory Aspects of Nutrition During Development

Location: Children's Nutrition Research Center

Title: Glutamine supplementation, citrulline production, and de novo arginine synthesis: Is there a relation?

Author
item Ligthart-melis, Gerdien
item Marini, Juan
item Engelen, Marielle
item Deutz, Nicolaas

Submitted to: American Journal of Clinical Nutrition
Publication Type: Other
Publication Acceptance Date: 3/30/2015
Publication Date: 4/1/2015
Citation: Ligthart-Melis, G.C., Marini, J.C., Engelen, M.P., Deutz, N.E. 2015. Glutamine supplementation, citrulline production, and de novo arginine synthesis: Is there a relation? [Letter to the Editor]. American Journal of Clinical Nutrition. 101(4):890-892.

Interpretive Summary:

Technical Abstract: We would like to comment on the recent publications by Buijs et al. The authors hypothesized that a parenteral supplement of glutamine stimulates citrulline formation and enhances de novo arginine synthesis. To test this hypothesis, they conducted an experiment with stable isotopes in patients undergoing abdominal surgery in the postprandial period. On the basis of an increase in plasma citrulline and arginine concentrations, the authors concluded that glutamine, in fact, increases citrulline and arginine production. We would like to explain in this letter why the article by Buijs et al. does not add any new information to their previous work and omits crucial new insights in the glutamine-citrulline-arginine pathways that have emerged since.

Last Modified: 10/17/2017
Footer Content Back to Top of Page