|RAJAO, DANIELA - Non ARS Employee|
|GAUGER, PHILLIP - Iowa State University|
Submitted to: Current Topics in Microbiology and Immunology
Publication Type: Book / Chapter
Publication Acceptance Date: 2/11/2014
Publication Date: 7/18/2014
Citation: Rajao, D.S., Anderson, T.K., Gauger, P.C., Vincent, A.L. 2014. Pathogenesis and vaccination of influenza A virus in swine. In: Compans, R.W., Oldstone, M.B.A., editors. Influenza Pathogenesis and Control, Current Topics in Microbiology and Immunology. Switzerland: Springer International Publishing. p. 307-326.
Technical Abstract: Swine influenza is an acute respiratory disease of pigs that is characterized by fever followed by lethargy, anorexia, and serous nasal discharge. The disease progresses rapidly and may be complicated when associated with other respiratory pathogens. Influenza A virus (IAV) is one of the most prevalent respiratory pathogens of swine, resulting in substantial economic burden to pork producers. In the past 10-15 years, a dramatic evolution of the IAV in U. S. swine has occurred, resulting co-circulation of many antigenically distinct IAV strains, derived from thirteen phylogenetically distinct hemagglutinin clusters of H1 and H3 viruses. Vaccination is the most common strategy to prevent influenza in pigs, however the current diverse IAV epidemiology poses a challenge for the production of efficacious and protective vaccines. A concern regarding the use of traditional inactivated vaccines is the possibility of inducing vaccine-associated enhanced respiratory disease (VAERD) when vaccine virus strains are mismatched with the infecting strain. In this review, we discuss the current epidemiology and pathogenesis of swine influenza in the United States, different vaccines platforms with potential to control influenza in pigs, and the factors associated with disease enhancement.