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United States Department of Agriculture

Agricultural Research Service

Research Project: Control of Ovine Respiratory Disease through Genetic and Immunologic Mitigation of Pathogen Transmission and Disease

Location: Animal Disease Research

Title: The sheep genome illuminates biology of the rumen and lipid metabolism )

item Jiang, Yu
item Xie, Min
item Chen, Wenbin
item Talbot, Richard
item Maddox, Jillian
item Faraut, Thomas
item Wu, Chunhua
item Muzny, Donna
item Li, Yuxiang
item Zhang, Wenguang
item Stanton, Jo-ann
item Brauning, Rudiger
item Barris, Wesley
item Hourlier, Thibaut
item Aken, Bronwen
item Searle, Stephen
item Adelson, David
item Bian, Chao
item Cam, Graham
item Chen, Yulin
item Chen, Shifeng
item Desilva, Udaya
item Dixen, Karen
item Dong, Yang
item Fan, Guangyi
item Franklin, Ian
item Fu, Shaoyin
item Fuentes-utrilla, Pablo
item Guan, Rui
item Highland, Margaret - Maggie
item Holder, Michael
item Huang, Guodong
item Ingham, Aaron
item Jhangiani, Shalini
item Kalra, Divya
item Kovar, Christie
item Lee, Sandra
item Liu, Weiqing
item Liu, Xin
item Lu, Changxin
item Lv, Tian
item Mathew, Tittu
item Mcwilliam, Sean
item Menzies, Moira
item Pan, Shengkai
item Robelin, David
item Servin, Bertrand
item Townley, David
item Wang, Wenliang
item Wei, Bin
item White, Stephen
item Yang, Xinhua
item Ye, Chen
item Yue, Yaojing
item Zeng, Peng
item Zhou, Qing
item Hansen, Jacob
item Kristensen, Karsten
item Gibbs, Richard
item Flicek, Paul
item Warkup, Christopher
item Jones, Huw
item Oddy, Hutton
item Nicholas, Frank
item Mcewan, John
item Kijas, James
item Wang, Jun
item Worley, Kim
item Archibald, Alan
item Cockett, Noelle
item Xun, Xu
item Wang, Wen
item Dalrymple, Brian

Submitted to: Science
Publication Type: Peer reviewed journal
Publication Acceptance Date: 5/7/2014
Publication Date: 6/6/2014
Citation: Jiang, Y., Xie, M., Chen, W., Talbot, R., Maddox, J.F., Faraut, T., Wu, C., Muzny, D.M., Li, Y., Zhang, W., Stanton, J., Brauning, R., Barris, W.C., Hourlier, T., Aken, B., Searle, S.M., Adelson, D.L., Bian, C., Cam, G.R., Chen, Y., Chen, S., Desilva, U., Dixen, K., Dong, Y., Fan, G., Franklin, I.R., Fu, S., Fuentes-Utrilla, P., Guan, R., Highland, M.A., Holder, M., Huang, G., Ingham, A.B., Jhangiani, S.N., Kalra, D., Kovar, C.L., Lee, S.L., Liu, W., Liu, X., Lu, C., Lv, T., Mathew, T., Mcwilliam, S., Menzies, M., Pan, S., Robelin, D., Servin, B., Townley, D., Wang, W., Wei, B., White, S.N., Yang, X., Ye, C., Yue, Y., Zeng, P., Zhou, Q., Hansen, J.B., Kristensen, K., Gibbs, R., Flicek, P., Warkup, C.C., Jones, H.E., Oddy, H., Nicholas, F.W., Mcewan, J.C., Kijas, J., Wang, J., Worley, K., Archibald, A.L., Cockett, N., Xun, X., Wang, W., Dalrymple, B.P. 2014. The sheep genome illuminates biology of the rumen and lipid metabolism. Science. 344(6188):1168-1173.

Interpretive Summary: Since their domestication about 11,000 years ago sheep have been a source of meat, milk and wool. Sheep are especially good at efficiently converting low value plant forage/feed into high value animal protein. To investigate the biological basis of their special characteristics, we have completed a high quality reference genome of domestic sheep and a detailed survey of gene expression across 40 tissues. We have identified two new groups of highly expressed genes associated with the evolution of the rumen, the specialized stomach that houses the microbes responsible for initial digestion of feed. We have also identified amplified gene number and/or altered tissue expression patterns of a number of genes involved in fat metabolism. This provides evidence to explain 1) the increased role of fatty acids in ruminants compared to animals with only one stomach, 2) unique properties of skin barrier fats in sheep relative to other animals, and 3) the interactions between fat metabolism and hair/wool synthesis.

Technical Abstract: Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.

Last Modified: 8/24/2016
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