Author
JIANG, YU - Chinese Academy Of Sciences | |
XIE, MIN - Beijing Genome Institute | |
CHEN, WENBIN - Beijing Genome Institute | |
TALBOT, RICHARD - University Of Edinburgh | |
MADDOX, JILLIAN - University Of Melbourne | |
FARAUT, THOMAS - Institut National De La Recherche Agronomique (INRA) | |
WU, CHUNHUA - Utah State University | |
MUZNY, DONNA - Baylor College Of Medicine | |
LI, YUXIANG - Beijing Genome Institute | |
ZHANG, WENGUANG - Chinese Academy Of Sciences | |
STANTON, JO-ANN - University Of Otago | |
BRAUNING, RUDIGER - Agresearch | |
BARRIS, WESLEY - Commonwealth Scientific And Industrial Research Organisation (CSIRO) | |
HOURLIER, THIBAUT - Wellcome Trust Sanger Institute | |
AKEN, BRONWEN - Wellcome Trust Sanger Institute | |
SEARLE, STEPHEN - Wellcome Trust Sanger Institute | |
ADELSON, DAVID - Commonwealth Scientific And Industrial Research Organisation (CSIRO) | |
BIAN, CHAO - Beijing Genome Institute | |
CAM, GRAHAM - Commonwealth Scientific And Industrial Research Organisation (CSIRO) | |
CHEN, YULIN - Northwest Agricultural & Forestry University | |
CHEN, SHIFENG - Beijing Genome Institute | |
DESILVA, UDAYA - Commonwealth Scientific And Industrial Research Organisation (CSIRO) | |
DIXEN, KAREN - University Of Copenhagen | |
DONG, YANG - Chinese Academy Of Sciences | |
FAN, GUANGYI - Beijing Genome Institute | |
FRANKLIN, IAN - Commonwealth Scientific And Industrial Research Organisation (CSIRO) | |
FU, SHAOYIN - Inner Mongolian Agriculture University | |
FUENTES-UTRILLA, PABLO - University Of Edinburgh | |
GUAN, RUI - Beijing Genome Institute | |
Highland, Margaret | |
HOLDER, MICHAEL - Baylor College Of Medicine | |
HUANG, GUODONG - Beijing Genome Institute | |
INGHAM, AARON - Commonwealth Scientific And Industrial Research Organisation (CSIRO) | |
JHANGIANI, SHALINI - Baylor College Of Medicine | |
KALRA, DIVYA - Baylor College Of Medicine | |
KOVAR, CHRISTIE - Baylor College Of Medicine | |
LEE, SANDRA - Baylor College Of Medicine | |
LIU, WEIQING - Beijing Genome Institute | |
LIU, XIN - Beijing Genome Institute | |
LU, CHANGXIN - Beijing Genome Institute | |
LV, TIAN - Beijing Genome Institute | |
MATHEW, TITTU - Baylor College Of Medicine | |
MCWILLIAM, SEAN - Commonwealth Scientific And Industrial Research Organisation (CSIRO) | |
MENZIES, MOIRA - Commonwealth Scientific And Industrial Research Organisation (CSIRO) | |
PAN, SHENGKAI - Beijing Genome Institute | |
ROBELIN, DAVID - Institut National De La Recherche Agronomique (INRA) | |
SERVIN, BERTRAND - Institut National De La Recherche Agronomique (INRA) | |
TOWNLEY, DAVID - Commonwealth Scientific And Industrial Research Organisation (CSIRO) | |
WANG, WENLIANG - Beijing Genome Institute | |
WEI, BIN - Beijing Genome Institute | |
White, Stephen | |
YANG, XINHUA - Beijing Genome Institute | |
YE, CHEN - Beijing Genome Institute | |
YUE, YAOJING - Chinese Academy Of Agricultural Sciences | |
ZENG, PENG - Beijing Genome Institute | |
ZHOU, QING - Beijing Genome Institute | |
HANSEN, JACOB - University Of Copenhagen | |
KRISTENSEN, KARSTEN - University Of Copenhagen | |
GIBBS, RICHARD - Baylor College Of Medicine | |
FLICEK, PAUL - European Bioinformatics Institute | |
WARKUP, CHRISTOPHER - Roslin Institute | |
JONES, HUW - Roslin Institute | |
ODDY, HUTTON - University Of New England | |
NICHOLAS, FRANK - University Of Sydney | |
MCEWAN, JOHN - Agresearch | |
KIJAS, JAMES - Commonwealth Scientific And Industrial Research Organisation (CSIRO) | |
WANG, JUN - Beijing Genome Institute | |
WORLEY, KIM - Baylor College Of Medicine | |
ARCHIBALD, ALAN - University Of Edinburgh | |
COCKETT, NOELLE - Utah State University | |
XUN, XU - Beijing Genome Institute | |
WANG, WEN - Chinese Academy Of Sciences | |
DALRYMPLE, BRIAN - Commonwealth Scientific And Industrial Research Organisation (CSIRO) |
Submitted to: Science
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 5/7/2014 Publication Date: 6/6/2014 Citation: Jiang, Y., Xie, M., Chen, W., Talbot, R., Maddox, J.F., Faraut, T., Wu, C., Muzny, D.M., Li, Y., Zhang, W., Stanton, J., Brauning, R., Barris, W.C., Hourlier, T., Aken, B., Searle, S.M., Adelson, D.L., Bian, C., Cam, G.R., Chen, Y., Chen, S., Desilva, U., Dixen, K., Dong, Y., Fan, G., Franklin, I.R., Fu, S., Fuentes-Utrilla, P., Guan, R., Highland, M.A., Holder, M., Huang, G., Ingham, A.B., Jhangiani, S.N., Kalra, D., Kovar, C.L., Lee, S.L., Liu, W., Liu, X., Lu, C., Lv, T., Mathew, T., Mcwilliam, S., Menzies, M., Pan, S., Robelin, D., Servin, B., Townley, D., Wang, W., Wei, B., White, S.N., Yang, X., Ye, C., Yue, Y., Zeng, P., Zhou, Q., Hansen, J.B., Kristensen, K., Gibbs, R., Flicek, P., Warkup, C.C., Jones, H.E., Oddy, H., Nicholas, F.W., Mcewan, J.C., Kijas, J., Wang, J., Worley, K., Archibald, A.L., Cockett, N., Xun, X., Wang, W., Dalrymple, B.P. 2014. The sheep genome illuminates biology of the rumen and lipid metabolism. Science. 344(6188):1168-1173. Interpretive Summary: Since their domestication about 11,000 years ago sheep have been a source of meat, milk and wool. Sheep are especially good at efficiently converting low value plant forage/feed into high value animal protein. To investigate the biological basis of their special characteristics, we have completed a high quality reference genome of domestic sheep and a detailed survey of gene expression across 40 tissues. We have identified two new groups of highly expressed genes associated with the evolution of the rumen, the specialized stomach that houses the microbes responsible for initial digestion of feed. We have also identified amplified gene number and/or altered tissue expression patterns of a number of genes involved in fat metabolism. This provides evidence to explain 1) the increased role of fatty acids in ruminants compared to animals with only one stomach, 2) unique properties of skin barrier fats in sheep relative to other animals, and 3) the interactions between fat metabolism and hair/wool synthesis. Technical Abstract: Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals. |