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United States Department of Agriculture

Agricultural Research Service

Research Project: ASTRAGALUS AND OXYTROPIS POISONING IN LIVESTOCK

Location: Poisonous Plant Research

Title: Detection of monofluoroacetate in Palicourea and Amorimia species)

Author
item Lee, Stephen
item Cook, Daniel
item Riet-correa, Franklin
item Pfister, James - Jim
item Anderson, William
item Lima, Flavia
item Gardner, Dale

Submitted to: Toxicon
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/31/2012
Publication Date: 6/11/2012
Publication URL: dx.doi.org/10.1016/j.toxicon.2012.05.029
Citation: Lee, S.T., Cook, D., Riet-Correa, F., Pfister, J.A., Anderson, W.R., Lima, F.G., Gardner, D.R. 2012. Detection of monofluoroacetate in Palicourea and Amorimia species. Toxicon. 60(5): 791-6.

Interpretive Summary: Numerous plant species worldwide including Palicourea marcgravii and Tanaecium bilabiatum in Brazil cause sudden death and are known to contain monofluoroacetate (MFA). Other plant species in Brazil are reported to cause sudden death in livestock and are suspected to contain MFA due to the similarity of clinical signs. In this study, a method to detect and quantify MFA was developed and was used to investigate plant material from field collections and/or herbarium specimens of Mascagnia, Amorimia, and Palicourea species suspected of causing sudden death. MFA was detected in Amorimia amazonica, A. camporum, A. exotropica, A. pubiflora, A. rigida, and A. septentrionalis as well as P. aeneofusca. MFA concentrations differ greatly between Palicourea species and Amorimia species, which may explain the incidence of poisoning and the amount of plant material required to cause sudden death between these taxa.

Technical Abstract: Numerous plant species worldwide including Palicourea marcgravii and Tanaecium bilabiatum in Brazil cause sudden death and are known to contain monofluoroacetate (MFA). Other species in Brazil including some species traditionally assigned to Mascagnia but now properly called Amorimia species and other Palicourea species are reported to cause sudden death in livestock and are suspected to contain MFA due to the similarity of clinical signs. In this study, an HPLC-APCI-MS method to detect and quantify MFA was developed and was used to investigate plant material from field collections and/or herbarium specimens of Mascagnia, Amorimia, and Palicourea species suspected of causing sudden death. MFA was detected in Amorimia amazonica, A. camporum, A. exotropica, A. pubiflora, A. rigida, and A. septentrionalis as well as P. aeneofusca. MFA concentrations differ greatly between Palicourea species and Amorimia species, which may explain the incidence of poisoning and the amount of plant material required to cause sudden death between these taxa.

Last Modified: 8/24/2016
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