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ARS Home » Midwest Area » West Lafayette, Indiana » Livestock Behavior Research » Research » Publications at this Location » Publication #267551

Title: Genetic variation in resistance to infection and inflammation

item Cheng, Heng-Wei

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 9/12/2011
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Genes determine functions of the neuroendocrine and immunological systems that affect an animal’s ability to cope with stress, resulting in resistance or susceptibility to infection and inflammation. In this study, genetic variation in responses to lipopolysaccharide (LPS) challenge were examined in chicken lines divergently selected for high (HGPS) and low (LGPS) group productivity and survivability resulting from cannibalism and flightiness in colony cages and in a Dekalb XL (DXL) commercial line selected individually for egg production. Six-week-old chicks were randomly assigned to control or experimental groups and were injected intravenously with Escherichia coli LPS (5 mg/kg BW) or distilled saline (control). Sickness responses were measured at 6, 12, 24, 48, and 72 h following injection (n=10). Although LPS induced widespread sickness symptoms in all of the treated chicks, the reactions were in a genotypic- and phenotypic-specific manner. Compared to both LGPS and DXL chicks, HGPS chicks had acute, transient behavioral and physical changes with less effect on BW gain and organ development as well as core temperature, which were in the order HGPS