|SHEN, CHWAN-LI - Texas Tech University|
|YEH, JAMES - Winthrop University Hospital|
|CHYU, MING-CHIEN - Texas Tech University|
|WANG, JIA-SHENG - University Of Georgia|
Submitted to: Pharmacological Research
Publication Type: Book / Chapter
Publication Acceptance Date: 3/25/2011
Publication Date: 4/11/2012
Citation: Shen, C., Yeh, J.K., Cao, J.J., Chyu, M., Wang, J. 2012. Green tea and bone health. Pharmacological Research. 64(2):155-161.
Technical Abstract: Osteoporosis is a major health problem in the elderly, particularly women. Epidemiological evidence has shown an association between tea consumption and the prevention of age-related bone loss in elderly women and men. Ingestion of green tea and green tea bioactive compounds may be beneficial in mitigating bone loss of this population and decreasing their risk of osteoporotic fractures. This review describes the effect of green tea and its bioactive components on bone health with an emphasis on the following: (i) the prevalence and etiology of osteoporosis, (ii) role of oxidative stress and inflammation in osteoporosis, (iii) effects of green tea and its active components on osteoblastogenesis and osteoclastogenesis from human, animal, as well as cell culture studies, (iv) possible mechanisms for the osteo-protective effects of green tea bioactive compounds, (v) other bioactive components in tea that benefit bone health, and (vi) a summary and future research direction of green tea and bone health. In general, tea and its bioactive components may decrease fracture risk by improving bone mineral density and supporting osteoblastic while suppressing osteoclastic activities.