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United States Department of Agriculture

Agricultural Research Service


Location: Genetics, Breeding, and Animal Health Research

Title: BTA2 and BTA26 are linked with bovine respiratory disease and associated with persistent infection of bovine viral diarrhea virus)

item Zanella, Ricardo
item Casas, Eduardo
item Snowder, Gary
item Wenz, John
item Neibergs, Joseph
item Moore, Dale
item Neibergs, Holly

Submitted to: Plant and Animal Genome Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 11/9/2010
Publication Date: 1/15/2011
Citation: Zanella, R., Casas, E., Snowder, G.D., Wenz, J., Neibergs, J.S., Moore, D., Neibergs, H.L. 2011. BTA2 and BTA26 are linked with bovine respiratory disease and associated with persistent infection of bovine viral diarrhea virus [abstract]. Plant and Animal Genome XIX Conference. Poster No. P522.

Interpretive Summary:

Technical Abstract: Bovine viral diarrhea virus is a pathogen associated with bovine respiratory disease (BRD). BRD causes 28% of all cattle deaths and an annual U.S. loss over $692 million. The objective of this study was to refine the linkage of BRD and association of bovine viral diarrhea-persistent infection (BVD-PI) on BTA2 and BTA26. One hundred seventy-four and 210 SNPs were chosen to cover a region of 15,262 and 14,021 kb on BTA2 and BTA26, respectively. Thirty SNPs on BTA2 and 29 SNPs on BTA26 were removed due to >10% failure or low MAF (<1%). Fine mapping for BRD was conducted with 2 crossbred families. Seventy-two BRD-affected and 146 BRD-unaffected half-sibs were analyzed with QTL Express (Seaton et al. 2002) using a one QTL model with 5,000 permutations to compute chromosome-wide F statistics. Association analysis was conducted with PLINK (Purcell et al. 2007) on 63 BVD-PI calves, 50 of their dams and 60 BVD-PI-unaffected calves from the same herds. Three animals (2 BVD-PI calves and 1 dam) were removed as <90% of their genotypes were called. Associations were determined, after Bonferroni correction, for BVD-PI calves compared to unaffected calves and for dams of BVD-PI calves and unaffected calves. BRD was linked (P<0.05) to BTA2 at 139,075,760 bp (Btau_4.0) and on BTA26 at 33,695,934 bp. An association (P<0.05) with BVD-PI calves was identified on BTA2 (137,385,203 bp) and BTA26 (132,168,986 bp) and with BVD-PI dams on BTA26 (42,551,644 bp and 46,608,559 bp) suggesting that loci linked with BRD are different than those associated with BVD-PI.

Last Modified: 05/26/2017
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