Submitted to: Genbank
Publication Type: Other
Publication Acceptance Date: 10/10/2008
Publication Date: 10/13/2008
Citation: Yeh, H., Klesius, P.H. 2008. Channel Catfish, Ictalurus punctatus, CD81 cDNA. Genbank. Accession No.FJ205473. Interpretive Summary:
Technical Abstract: CD81, also known as the target of an antiproliferative antibody (TAPA) is a member of tetraspanin integral membrane protein family. This protein plays many important roles in immune functions. In this communication, we cloned, sequenced and characterized the channen catfish CD81 transcript. The complete nucleic acid sequence of channel catfish CD81 cDNA comprised of 1,130 nucleotides, including an open reading frame, which appears to encode a putative peptide of 234 amino acid residues. By comparison with human CD81, the channel catfish CD81 peptide can be divided into domains, including four transmembrane domains, three intracellular domains, and one of each small and large extracellular loops. The channel catfish, CD81 transcript was detected by RT-PCR in speen, head kidney, liver, intestine, skin and gill. This result provides important information for further elucidating CD81 in channel catfish.