Submitted to: American Chemical Society Midwest Regional Meeting
Publication Type: Abstract Only
Publication Acceptance Date: 9/12/2008
Publication Date: 9/15/2008
Citation: Zimmerli, M.K., Tabatabai, L.B. 2008. Development of Peptide Vaccine Strategy for Avian and Swine Respiratory Diseases [abstract]. American Chemical Society Midwest Regional Meeting, October 5-8, 2008, Kearney, Nebraska. Abstract No. 95.
Technical Abstract: Two major outer membrane proteins identified to be of importance in Haemophilus influenzae are OMP P2 and OMP P5. Both proteins have been found to be important in the establishment of colonization as well as having bactericidal activity in animal models. Previously, the homologs of these proteins were identified in Haemophilus parasuis, a swine respiratory pathogen, and Ornithobacterium rhinotracheale, an avian respiratory pathogen. These pathogens are associated with economic loss in their respective industry, making necessity great for the availability of a commercially available vaccine. By combining molecular modeling techniques and primary sequence analysis, we have designed peptide-based vaccine and diagnostic candidates for both organisms.