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ARS Home » Midwest Area » Urbana, Illinois » Global Change and Photosynthesis Research » Research » Publications at this Location » Publication #213923
Title: Functional Analysis and Phosphorylation Site Mapping of Leucine-Rich Repeat Receptor-Like Kinases

Author
item CLOUSE, S - NC STATE UNIVERSITY
item GOSHE, M - NC STATE UNIVERSITY
item Huber, Steven
item LI, J - UNIVERSITY OF OKLAHOMA

Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 6/1/2007
Publication Date: 6/1/2008
Citation: Clouse, S.D., Goshe, M.B., Huber, S.C., Li, J. 2008. Functional Analysis and Phosphorylation Site Mapping of Leucine-Rich Repeat Receptor-Like Kinases. In: Agrawal, G.K., Rakwal, R., editors. Plant Proteomics: Technologies, Strategies, and Applicatioins. Hoboken, NJ: John Wiley & Sons, Inc. p. 469-484.

Interpretive Summary:

Technical Abstract: The completed genome sequences of Arabidopsis thaliana and rice have revealed very large multi-gene families encoding predicted proteins with an organization of functional domains similar to that of animal receptor kinases, including a putative extracellular ligand-binding domain, a single-pass transmembrane sequence and an intracellular cytoplasmic kinase domain. Such structural features suggest a role for these proteins in extracellular signal perception followed by intracellular transduction of the signal via phosphorylation of specific targets. More than 220 of these receptor-like kinases in Arabidopsis and nearly 400 in rice have an extracellular domain containing multiple leucine-rich repeats and are thus classified as Leucine-Rich Repeat Receptor-Like Kinases (LRR RLKs). LRR RLKs can be further divided into 15 sub-families based on sequence alignment. A small subset of these LRR RLKs have been characterized in detail by genetic and biochemical analyses and have been shown to play essential roles in regulating plant growth and development as well as in defense responses to various pathogens.