Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 10/1/2006
Publication Date: 10/1/2006
Citation: Dow, C., Sahin, O., Muraoka, W.T., Wesley, I.V., Zhang, Q. 2006. Antimicrobial resistance rates in Campylobacter isolates derived from swine [abstract]. Food Safety Consortium 2006 Symposium. October 1-3, 2006. Fayetteville, Arkansas. 2006 CDROM.
Technical Abstract: Campylobacter, a microaerophilic gram-negative rod, is a major foodborne pathogen and commonly present in swine intestinal tract without causing any clinical disease. In this project, we investigated the antimicrobial resistance profiles of fecal Campylobacter isolates (n= 194) obtained from a swine farm at different production stages including piglets (n=94), midway piglets (n=21), end-nursery piglets (n=38), mid-finisher pigs (n=23), and end-finisher pigs (n=18). Using the standardized agar dilution test, susceptibility of the Campylobacter isolates to antimicrobial agents including gentamicin, meropenem, ciprofloxacin, erythromycin, and doxycycline were determined according to the CLSI recommendation. Among the examined C. coli isolates, overall resistance rates of 0, 0, 0, 56.7%, and 39.2% were detected against gentamicin, meropenem, ciprofloxacin, erythromycin, and doxycycline, respectively. The following resistance rates were observed against erythromycin and doxycycline, respectively, at each stage of the production: piglets (37.2%, 52.1%), midway piglets (52.4%, 85.7%), end-nursery piglets (21.1%, 78.9%), mid-finishers (73.9%, 34.8%), and end-finishers (27.8%, 27.8%). These results indicated that although ciprofloxacin resistance was not present in C. coli isolates from swine, resistance to other clinically important drugs (e.g., erythromycin and doxycycline) was common, occurring at multiple stages of the production cycle. These findings plus our ongoing studies will reveal new information on the epidemiology of antibiotic resistant Campylobacter in swine, which will be useful for reducing the occurrence and transmission of antibiotic resistant foodborne pathogens.