Submitted to: Electronic Publication
Publication Type: Other
Publication Acceptance Date: 2/18/2005
Publication Date: 3/1/2005
Citation: Jeha, G., Haymond, M.W., 2005. Clinical features and diagnosis of diabetic ketoacidosis in children. UpToDate.com. Rose B.D., Wellesley, MA: Up To Date. Available: http://www.uptodate.com. Interpretive Summary:
Technical Abstract: Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in children with type 1 diabetes mellitus (DM). DKA also can occur children with type 2 DM, particularly in obese African-American adolescents. In recent years, the incidence and prevalence of type 2 diabetes mellitus have increased across all ethnic groups. This has been coupled with an increasing awareness that children with type 2 DM can present with ketosis or DKA, particularly obese African American adolescents. The clinical features and diagnosis of DKA in children will be reviewed here. This discussion is primarily based upon the large collective experience of children with type 1 DM. There is limited experience in the assessment and diagnosis of DKA in children with type 2 DM, although the same principles should apply. The treatment of DKA in children and the pathogenesis of DKA are discussed elsewhere.