Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: 6/1/2006
Publication Date: 7/31/2006
Citation: Bulach, D., Seemann, T., Zuerner, R.L., Adler, B. 2006. The organization of leptospira at a genomic level. In: Chan, V.L., Sherman, P.M., Bourke, B., editors. Bacterial Genomes and Infectious Diseases. Totowa, USA: Humana Press. p. 109-123.
Interpretive Summary: Genomic sequence analysis is a useful and efficient method to help characterize the biology and disease causing potential of pathogenic bacteria. Several laboratories are using this approach to characterize the bacteria that cause leptospirosis, an important disease in livestock, companion animals, and humans. To facilitate comparison of data between laboratories, we propose using uniform methods to analyze and name Leptospira genes.
Technical Abstract: The complete nucleotide sequences of three, and in the not too distant future, six strains from the genus Leptospira will be available. Managing and maintaining these data will be a perpetual problem unless a system is devised to address this issue. We propose a central role for the IUMS Subcommittee on the Taxonomy of Leptospira in maintaining and updating the annotated leptospiral genome sequences. The first step in this process is provided as part of this publication, namely a revision of the annotation of the three published genomes and an internet location for the current versions of these genomes.