|Lee, Joo young|
Submitted to: Review Article
Publication Type: Review article
Publication Acceptance Date: 3/31/2007
Publication Date: 3/31/2007
Citation: Lee, J., Hwang, D.H. The modulation of inflammatory gene expression by lipids: mediation through toll-like receptors. Review Article. 2006. Molecules and Cells, Vol.21,No.2,pp.174-185. Interpretive Summary:
Technical Abstract: TLRs were evolved to detect invading pathogens and to induce innate immune responses in order to mount host defense mechanisms. It becomes apparent that the activation of some TLRs is also modulated by endogenous molecules including lipid components, fatty acids. Results from epidemiological and animal studies demonstrated that saturated and polyunsaturated dietary fatty acids can differentially modify the risk of development of many chronic diseases. Inflammation is now recognized as an important underlying etiologic condition for the pathogenesis of many chronic diseases. Therefore, if the activation of TLRs and consequent inflammatory and immune responses are also differentially modulated by types of lipids in vivo, this would suggest that the risk of chronic inflammatory diseases and host defense against microbial infection may also be modified by the pattern and the consumption behaviors of dietary fat.