Submitted to: Invention Report
Publication Type: Patent Application
Publication Acceptance Date: 1/31/2006
Publication Date: 1/31/2006
Citation: Shoemaker, C.A., Klesius, P.H., Evans, J.J. 2006. Method of protecting fish against columnaris disease with modified live Flavobacterium columnare. U.S. Patent US 6,991,793 B2.
Technical Abstract: Safe and effective live vaccines against Flavobacterium columnare of fish were created through the induction of rifampicin resistance in a native Flavobacterium columnare isolate; these including rifampicin-resistant mutants NRRL B-30303 and B30304. Single immersion exposure of fish stimulated acquired immunity against virulent F. columnare infection.