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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #191152
Title: USE OF CHOLECYSTOKININ-OCTAPEPTIDE FOR THE PREVENTION OF PARENTERAL NUTRITION-ASSOCIATED CHOLESTASIS

Author
item TEITELBAUM, DANIEL - UNIV OF MICHIGAN
item TRACY, THOMAS - BROWN MEDICAL SCHOOL
item AOUTHMANY, MOUSTAFA - ST VINCENTS MERCY CHILD H
item LLANOS, ADOLFO - UNIV OF ROCHESTER
item BROWN, MORTON - UNIV OF MICHIGAN
item YU, SUNKUNG - UNIV OF MICHIGAN
item BROWN, MARILYN - UNIV OF ROCHESTER
item Shulman, Robert
item HIRSCHL, RONALD - UNIV OF MICHIGAN
item DERUSSO, PATRICIA - JOHNS HOPKINS U SCH MED
item COX, JEANNE - JOHNS HOPKINS U SCH MED
item DAHLGREN, JACQUELINE - UNIV OF MICHIGAN
item GRONER, JONATHAN - UNIV OF MICHIGAN
item STROUSE, PETER - UNIV OF MICHIGAN

Submitted to: Pediatrics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/28/2004
Publication Date: 5/1/2005
Citation: Teitelbaum, D.H., Tracy, T.F., Aouthmany, M.M., Llanos, A., Brown, M.B., Yu, S., Brown, M.R., Shulman, R.J., Hirschl, R.B., Derusso, P.A., Cox, J., Dahlgren, J., Groner, J.I., Strouse, P.J. 2005. Use of cholecystokinin-octapeptide for the prevention of parenteral nutrition-associated cholestasis. Pediatrics. 115(5):1332-1340.

Interpretive Summary: Many preterm infants must receive intravenous feedings because they are too immature to tolerate feeding into their gastrointestinal tracts. Although this type of feeding can be lifesaving, it also can, in association with other factors, cause severe and even life threatening liver disease. A hormone that the body normally makes, cholecystokinin, has been proposed as a potential treatment to prevent this liver disease. This study tested whether a synthetic version of cholecystokinin could prevent liver disease in preterm infants receiving intravenous feedings. Infants were randomized to receive cholecystokinin or placebo. Unfortunately, the cholecystokinin did not appear to prevent the liver disease.

Technical Abstract: Objective. To determine whether cholecystokinin-octapeptide (CCK-OP) would prevent or ameliorate parenteral nutrition-associated cholestasis (PNAC) among high-risk neonates treated with total parenteral nutrition. Study Design. This was a multicenter, double-blind, randomized, controlled trial conducted between 1996 and 2001. Patients. Neonates at risk for the development of PNAC included very low birth weight neonates and those with major surgical conditions involving the gastrointestinal tract. Setting. Tertiary care hospitals. Intervention: Patients were randomized to receive CCK-OP (0.04 'g/kg per dose, twice daily) or placebo. Eligible infants were all <30 days of age. Patients were enrolled within 2 weeks after birth or within 7 days after surgery. Outcome Measures. The primary outcome measure was conjugated bilirubin (CB) levels, which were measured weekly. Secondary outcome measures included incidence of sepsis, times to achieve 50% and 100% of energy intake through the enteral route, number of ICU and hospital days, mortality rate, and incidences of biliary sludge and cholelithiasis. Results. A total of 243 neonates were enrolled in the study. CCK-OP administration did not significantly affect CB levels (1.76 +/- 3.14 and 1.93 +/- 3.31 mg/dL for CCK-OP and placebo groups, respectively; mean +/- SD). Secondary outcome measures also were not significantly affected by the study drug. Conclusions. Use of CCK-OP failed to reduce significantly the incidence of PNAC or levels of CB. CCK-OP had no effect on other secondary measures and should not be recommended for the prevention of PNAC.