Submitted to: Swine Disease Conference Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 11/11/2004
Publication Date: 11/11/2004
Citation: Richt, J.A., Lager, K.M., Lekcharoensuk, P., Janke, B.H., Solorzano, A., Garcia-Sastre, A., Webby, R.J. 2004. Swine influenza: diversity of U.S. virus isolates and novel vaccine approaches. In: Proceedings of the Twelfth Annual Swine Disease Conference for Swine Practitioners, Iowa State University, November 11-12, 2004, Ames, Iowa. p. 40-44.
Technical Abstract: Swine influenza (SI) is an acute respiratory disease of swine caused by type A influenza viruses. Before 1998, mainly H1N1 SI viruses (SIV) were isolated from swine in the U.S. Since then, antigenetically distinct reassortant H3N2 and H1N1 SIVs have been identified as causative agents of respiratory disease in pigs on U.S. farms. The ongoing reassortment of swine influenza viruses with three subtypes of influenza virus presently circulating in the U.S. swine herd has important implications for the efficacy of current SIV vaccines. Monovalent vaccines based on various H3N2 cluster viruses were not able to induce protective immunity against all H3N2 SIVs used for challenge. The establishment of the reverse genetics system for swine influenza viruses might allow us to develop novel live attenuated virus vaccines.