Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 12/1/2004
Publication Date: 3/7/2005
Citation: Keck, A-S., Finley, J.W. 2005. Broccoli improved lipid values and selenium-enriched broccoli increased plasma selenium in healthy males [abstract]. The Federation of American Societies for Experimental Biology Journal. 19(5):A1454.
Technical Abstract: Epidemiologic evidence suggests consumption of selenium (Se) and/or broccoli protects against cancer and cardiovascular disease. Animal studies suggest that broccoli may improve antioxidant status and induce phase II proteins. The objective of this study was to determine if a daily intake of 9 or 90 g of regular or Se-enriched broccoli for 6 wks improved measures of Se, antioxidant status and clinical health (e.g. lipids, liver function and hematology). Thirty healthy men consumed 1 of 3 diets: 1) broccoli (0.03 ppm Se), 2) broccoli with 3 ppm added Se, and 3) Se-enriched broccoli (3 ppm Se). Broccoli in a ready-to-eat dish was consumed with self-selected diets; 9g broccoli/d for 6 wks and after a 2 wk washout period they consumed 90g broccoli/d for an additional 6 wks. Se-Enriched Broccoli Broccoli + Selenate Broccoli Analysis 9g 90g 9g 90g 9g 90g Cholesterol total (mg/dL) 209±13 204±13 210±11 213±14 202±11 205±13 LDL (mg/dL)* 136±11 120±9 136±9 131±10 134±10 131±10 HDL (mg/dL)* 48.5±2.4 53.4±3.0 42.7±2.6 47.5±3.2 47.0±3.2 49.9±3.4 LDL/HDL* 2.9±0.3 2.4±0.3 3.3±0.2 2.9±0.3 2.9±0.2 2.7±0.3 Plasma Se (micro g/ml) 133±6 149±6 135±4 141±3 138±4 137±4 * significant effect of amount of broccoli; data are means ± SD. These data suggest a novel benefit of broccoli consumption may be significant improvement of blood lipid status. Consumption of Se-enriched broccoli for 6 wks caused only a modest (12%) increase in plasma Se.