|Chase, Chadwick - Chad|
|Smith, Timothy - Tim|
Submitted to: Plant and Animal Genome VX Conference Abstracts
Publication Type: Abstract only
Publication Acceptance Date: 11/4/2004
Publication Date: 1/15/2005
Citation: White, S.N., Casas, E., Wheeler, T.L., Shackelford, S.D., Koohmaraie, M., Riley, D.G., Chase, C.C., Johnson, D.D., Keele, J.W., Smith, T.P. 2005. A new snp marker in capn1 is associated with tenderness in cattle of indicine, taurine, and admixed descent. Proc., Plant & Animal Genome XIII, San Diego, CA. P528. p. 203. 2005. Interpretive Summary:
Technical Abstract: Despite the importance of beef tenderness to consumer satisfaction, it has been difficult to use selection to improve this trait. Two molecular markers in the CAPN1 gene have been proposed which allow selection in Bos taurus cattle, but neither marker segregates at high frequency in Brahman cattle. In this study, we examined additional SNPs in the CAPN1 gene for association with tenderness in a large, multi-sire American Brahman population. One (marker 2) was associated with Warner-Bratzler shear force on days 7, 14, and 21 post-slaughter in this population, showing that genetic variation important for tenderness does segregate in Bos indicus cattle at or near CAPN1. Marker 2 was also tested for association with shear force in two other large, multi-sire populations of cattle, the first of strictly Bos taurus descent, and the second with historically admixed subspecies descent. The highly significant association of marker 2 with shear force in these populations confirms the usefulness of marker 2 in cattle of all subspecies backgrounds, including Bos taurus, Bos indicus, and admixed descent. Because of this wide applicability, marker 2 may replace previously used markers in CAPN1 in many situations. However, the previously released marker resulting in the G316A substitution was highly associated with shear force in the population of admixed descent and had a larger effect than marker 2 in both the pure Bos taurus and admixed populations. Thus, it may continue to be useful in a variety of populations with high percentage Bos taurus backgrounds.