Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 8/1/2004
Publication Date: 9/27/2004
Citation: Smith, T.P., Snelling, W.M., Casas, E. 2004. Analysis of linkage disequilibrium in the region surrounding a quantitative trait locus for growth in cattle. Proc., Genome Sequencing & Analysis Conference XVI, Washington, DC, Sept. 27-30, 2004. Abstract P-56. p. 46.
Technical Abstract: Sequencing of the bovine genome is well underway, and will have a significant impact on research related to meat production in addition to the role of cattle as a model species for human disease. We are analyzing quantitative trait loci for growth in cattle. One lies on bovine chromosome 6 and affects weights at birth, weaning and at one year of age. It also affects average daily gain, hot carcass weight and loin muscle area. Using a population that includes over 570 crossbred steers from 147 different purebred sires of seven different breeds, SNP markers distributed across the quantitative trait loci region of the chromosome were analyzed to detect the extent of linkage disequilibrium, and were tested for association with growth traits. An interesting pattern of association was observed in which the significance of association increased incrementally as marker position moved from either side toward the center of the quantitative trait loci probability distribution, suggesting linkage disequilibrium extending for some distance even in this mulitbreed population.