Submitted to: Swine Disease Conference Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 9/1/2003
Publication Date: 11/6/2003
Citation: Richt, J., Lager, K.M., Janke, B.H., Webby, R.J. SIV diversity: implications for vaccine efficacy. 2003. In: Proceedings of the 11th Annual Swine Disease Conference for Swine Practitioners, November 6-7, 2003, Iowa State University, Ames, Iowa. P. 10-14. Interpretive Summary:
Technical Abstract: This study was undertaken to examine whether different clusters of H3N2 SIVs containing phylogenetically distinct HA molecules were also antigenically distinct. Using various in vitro and in vivo tests we found that cluster I and cluster III viruses appear to be antigenically similar whereas cluster II virus is antigenically dissimilar to both cluster I and III viruses. This could significantly affect vaccine efficacy of H3N2 vaccines when several clusters of H3N2 viruses circulate in the pig population and the commercially available SIV vaccines are based on a single prototype H3N2 virus.