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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #149501
Title: ZINC METABOLISM AND ZINC KINETICS IN CHILDREN WITH STABLE CROHN'S DISEASE (CD)

Author
item GRIFFIN, IAN - BAYLOR COL OF MED
item KIM, SANDRA - BAYLOR COL OF MED
item Abrams, Steven

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 12/1/2000
Publication Date: 3/31/2001
Citation: GRIFFIN,I.J., KIM,S.C., ABRAMS,S.A., ZINC METABOLISM AND ZINC KINETICS IN CHILDREN WITH STABLE CHRON'S DISEASE (CD), JOURNAL OF FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, 2001. v. 15(5). p. A965. Abstract No. 743.3.

Interpretive Summary: Not required

Technical Abstract: CD is a relatively common transmural inflammatory disease of the gastro-intestinal tract. Some of the later manifestations of CD are similar to the symptoms of zinc deficiency, but there are few data regarding zinc metabolism in children with CD. To examine zinc metabolism using a multi-compartmental stable-isotope based model in children with stable CD (n=5) and healthy controls (C, n=11). Subjects received 0.4 mg 70-zinc iv and 2 mg 67-zinc orally. Multiple blood samples were taken over the next six days and a complete urine and fecal collection was carried out. Tracer-tracee ratio was measured by thermal ionization mass spectrometry and data were modeled using a previously described 6-compartment model; comprised of three tissue compartments (a central "plasma" compartment, which has bi-directional exchanges to "fast" and "slow" turning over tissue compartments) and three gastro-intestinal compartments. Zinc absorption was measured from the fractional urinary excretion of the intravenous and oral isotopes at 48hrs. Endogenous fecal excretion (excretion of zinc from the body in to the gut) was measured from the urinary and fecal excretion of zinc and the intravenous isotope. Subjects with CD had lower plasma zinc concentrations (0.87±0.14 vs. 1.06±0.12, p=0.02), lower zinc absorption (7.39±4.0% vs. 19.6±13.2, p=0.07), and higher endogenous fecal zinc excretion (0.08±0.02mg/kg/d vs. 0.04+0.01, p<0.001) than C. Compartmental modeling showed no change in Ml (the central "plasma" compartment; 0.07±0.01mg/kg vs. 0,06±0.02, p=0.41), but M2 (the "fast" tissue compartment) tended to fall (0.19±0.16mg/kg vs. 0.40±0.23, p=0.08). There was a paradoxical increase in the "slow" tissue compartment (M3;4.89±1.95mg/kg vs 1.97+0.52, p=0.003). There was a significant increase in turnover between the plasma and tissue compartments. Zinc metabolism is abnormal in stable CD, this is reflected by significant changes in compartmental masses and inter-compartmental turnover.