Skip to main content
ARS Home » Plains Area » College Station, Texas » Southern Plains Agricultural Research Center » Food and Feed Safety Research » Research » Publications at this Location » Publication #146900
Title: EFFECT OF 2-NITROPROPANOL ON SALMONELLA TYPHIMURIUM CONCENTRATIONS IN THE CECA OF BROILER CHICKS

Author
item Jung, Yong Soo
item Anderson, Robin
item Edrington, Thomas
item Genovese, Kenneth - Ken
item Callaway, Todd
item Byrd Ii, James - Allen
item MCREYNOLDS, JACK - TX A&M UNIVERSITY
item Harvey, Roger
item Nisbet, David

Submitted to: Western Section of Animal Science Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 3/26/2003
Publication Date: 6/22/2003
Citation: Jung, Y., Anderson, R.C., Edrington, T.S., Genovese, K.J., Callaway, T.R., Byrd II, J.A., McReynolds, J., Harvey, R.B., Nisbet, D.J. 2003. Effect of 2-nitropropanol on Salmonella typhimurium concentrations in the ceca of broiler chicks. Proceedings of Western Section American Society of Animal Science. 54:107-107.

Interpretive Summary:

Technical Abstract: The bactericidal effect of 2-nitropropanol (2NPOH) was determined in vivo. Chicks were orally challenged with approximately 10**6 CFU per ml of Salmonella Typhimurium at 6 days of age. Chicks were then divided into three groups: control (0 mg 2NPOH/bird), 0.5X (6.5 mg 2NPOH/bird), and 1X (13 mg 2NPOH/bird) and treatments were administered orally one day post challenge. Cecal contents collected at necropsy 24 and 48 h after treatment were subjected to bacterial and volatile fatty acid analysis. Mean +/- SD populations of Salmonella were reduced (P < 0.05) in the group administered 1X (13 mg/bird) treatment at both the 24 and 48 h samplings compared to untreated control (2.58 +/- 2.10 versus 4.64 +/- 1.79 and 2.88 +/- 2.78 versus 5.03 +/- 2.42; 24 and 48 h, respectively). Analysis of volatile fatty acid (VFA) accumulation in cecal contents showed that concentrations of propionate, but not acetate or butyrate, were reduced (P < 0.05) by 1X treatment. Mean concentrations of total VFA within 2NPOH treated groups were not significantly different at 24 and 48 h. Results obtained in this study suggest there is potential applicability of 2NPOH as a bactericidal supplement against Salmonella in poultry.