Submitted to: Meeting Abstract
Publication Type: Abstract only
Publication Acceptance Date: 4/25/2000
Publication Date: N/A
Citation: Interpretive Summary:
Technical Abstract: A bovine viral diarrhea virus (BVDV-C) was isolated from swine tissue culture cells used to attenuate the transmissible gastroenteritis virus (TGEV); 68 passes. Piglets given a pure culture of BVDV-C developed clinical signs similar to that of a mild TGEV infection and recovered by ten days post exposure. Villous blunting and fusion was observed in the small intestine and a lymphocyte depletion was observed in Peyer's patches in the ileum. Piglets given a combination of BVDV-C and attenuated TGEV developed clinical signs similar to a virulent TGEV infection and were euthanized. The combine infection induced a generalized lymphocyte depletion throughout the lymphatic system along with villous atrophy in the intestinal tract. Piglets exposed to another Type I strains of BVDV (NY-1) either alone or in combination with the attenuated TGEV had mild clinical signs similar to a TGEV infection. Moderate villous atrophy in the ileum and a lymphocyte depletion in the mesenteric lymph node were observed in these piglets at post-mortem. The data indicate a potential problem for diagnostic laboratories in relation to a diagnosis of virulent TGEV infections and in the field for young piglets exposed to a BVDV contaminated TGEV vaccine.