Author
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Carlson, Steven |
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FRANA, TIMOTHY - IOWA STATE UNIVERSITY |
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GRIFFITH, RONALD - IOWA STATE UNIVERSITY |
Submitted to: Applied and Environmental Microbiology
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 5/23/2001 Publication Date: N/A Citation: N/A Interpretive Summary: Microcin 24 is protein secreted by pathogenic E. coli. Secretion of microcin 24 provides an antibacterial defense mechanism to E. coli. This antibacterial defense mechanism allows E. coli to survive by disabling neighboring bacteria especially Salmonella. However, we found that Salmonella could develop resistance to microcin 24 via activation of a multiple antibiotic resistance pathway. This study suggests that exposing Salmonella to sublethal levels of microcin 24 can create multiple antibiotic resistance in this pathogen. This would be of benefit to the Food and Drug Administration, Animal and Plant Health Inspection Service, pharmaceutical companies, and veterinary practitioners. Technical Abstract: Microcin 24 is an antimicrobial peptide secreted by uropathogenic E. coli. Secretion of microcin 24 provides an antibacterial defense mechanism to E. coli. For Salmonella, we found that resistance to microcin 24 could be induced by inhibiting marR, the repressor of the efflux-mediated multiple antibiotic resistance (mar) phenotype, and reversed by ancillary expression of marR. |