Location: Obesity and Metabolism Research
Project Number: 2032-51530-025-064-S
Project Type: Non-Assistance Cooperative Agreement
Start Date: Jun 1, 2021
End Date: Dec 31, 2021
Perform research focused on the role of dietary choline in the development of atherosclerosis as outlined in Agreement #58-2032-0-045, “Biological Mechanisms Through Which trimethylamine N-oxide (TMAO) Promotes Atherosclerosis”. These studies seek to determine the genetic regulation of plasma trimethylamine N-oxide using studies in 2 genetic reference panel of mice called the Hybrid mouse diversity panel and Diversity Outbred population.
UC Davis will support studies focused on trimethylamine N-oxide (TMAO) by employing full and part time technical personnel required to accomplish the proposed research. UC Davis will provide project management and advanced statistical data analysis of mouse studies, and microbiota analysis. ARS will generate metabolomics data and quality appropriate quality control prior to statistical analysis.