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ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Obesity and Metabolism Research » Research » Research Project #440281

Research Project: Genetic Studies of Choline Driven TMAO Production

Location: Obesity and Metabolism Research

Project Number: 2032-51530-025-064-S
Project Type: Non-Assistance Cooperative Agreement

Start Date: Jun 1, 2021
End Date: Dec 31, 2021

Perform research focused on the role of dietary choline in the development of atherosclerosis as outlined in Agreement #58-2032-0-045, “Biological Mechanisms Through Which trimethylamine N-oxide (TMAO) Promotes Atherosclerosis”. These studies seek to determine the genetic regulation of plasma trimethylamine N-oxide using studies in 2 genetic reference panel of mice called the Hybrid mouse diversity panel and Diversity Outbred population.

UC Davis will support studies focused on trimethylamine N-oxide (TMAO) by employing full and part time technical personnel required to accomplish the proposed research. UC Davis will provide project management and advanced statistical data analysis of mouse studies, and microbiota analysis. ARS will generate metabolomics data and quality appropriate quality control prior to statistical analysis.