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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Research Project #437176

Research Project: Development of a Transgenic Mouse that Expresses the Bovine Prion Polymorphism T231

Location: Virus and Prion Research

Project Number: 5030-32000-228-010-S
Project Type: Non-Assistance Cooperative Agreement

Start Date: Aug 1, 2019
End Date: Jul 31, 2022

Objective:
Develop a mouse model to test the susceptibility of the bovine T231 prion polymorphism to various prion agents.

Approach:
Transgene constructs will be used for microinjection into fertilized eggs and generation of the founder pups. Transgene constructs will be generated, characterized and maintained over the 2 year period to determine if transgene lines will develop a spontaneous prion disease.