Location: Virus and Prion Research
Project Number: 5030-32000-228-010-S
Project Type: Non-Assistance Cooperative Agreement
Start Date: Aug 1, 2019
End Date: Jul 31, 2023
Develop a mouse model to test the susceptibility of the bovine T231 prion polymorphism to various prion agents.
Transgene constructs will be used for microinjection into fertilized eggs and generation of the founder pups. Transgene constructs will be generated, characterized and maintained over the 2 year period to determine if transgene lines will develop a spontaneous prion disease.