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ARS Home » Northeast Area » Orient Point, New York » Plum Island Animal Disease Center » Foreign Animal Disease Research » Research » Research Project #436876

Research Project: Vesicular Stomatitis as a Model for a Predictive Disease Ecology

Location: Foreign Animal Disease Research

Project Number: 8064-32000-059-04-S
Project Type: Non-Assistance Cooperative Agreement

Start Date: Aug 1, 2019
End Date: Jul 31, 2022

Objective:
This cooperative research agreement establishes a new collaboration with experts at NMSU who bring to the project new expertise in viral disease ecology. The project will leverage and enhance ongoing Grand Challenge project in collaboration with USDA ARS Jornada Experimental Range. Specific Objectives: 1. Determine the relative roles of environmental factors, vector biology and virus phylogeny on the patterns of focal endemism and large-scale spread of epidemic Vesicular Stomatitis Virus (VSV) strains. 2. Develop parameters toward an early warning system for VS in Mexico that will assist USDA-APHIS and livestock owners in preparing for VS outbreaks in the U.S. 3. Determine if the information learned from VSV ecology and predictive models can be applied toward predicting ecological drivers of other arboviral diseases. AMENDMENT 01: 4. Assess potential role of target wildlife species within the VSV incursion corridor to serve as reservoir and amplifying hosts of VSV. 5. Monitor target vectors along the VSV incursion corridor for infection with VSV and use this information to refine predictions of the timing and path of VSV emergence from Mexico into the U.S.

Approach:
1. A collaboration will be established with Mexico's Exotic Animal Disease Commission (EADC) Mexico collaborators to carry out surveillance, field sampling and data collection regarding VSV in endemic and non-endemic regions. 2. Existing on-line data on the environment, vectors, and hosts from endemic regions within Mexico and the US will be mined and synthesized for use in building models. 3. Selected field samples, such as insects, sera and virus from Mexico will be sent to ARS laboratories at PIADC or ABDRU for further study. 4. Environmental, field and laboratory data will be integrated and used to build disease ecology predictive models, such as early warning disease model. AMENDMENT 01: 5. Vector insects collected in the US will be genetically barcoded and screened for VSV infection.