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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Parasitic Diseases Laboratory » People & Locations » Wenbin Tuo

Wenbin Tuo
Animal Parasitic Diseases Laboratory
Research Animal Scientist

Phone: (301) 504-8258
Fax: (301) 504-5306
Room 208

10300 BALTIMORE AVENUE
BLDG 1040 BARC-EAST
BELTSVILLE, MD 207052350
Projects
Immune, Molecular, and Ecological Approaches for Attenuating GI Nematode Infections of Ruminants
In-House Appropriated (D)
  Accession Number: 431978
Antigen Presenting Neutrophils in Cattle
Reimbursable Cooperative Agreement (R)
  Accession Number: 436673
Molecular Mechanisms Regulating Ostertagia ostertagi Infection in Cattle
Non-Assistance Cooperative Agreement (S)
  Accession Number: 436120

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Repeated, drug-truncated infections with Ostertagia ostertagi elicit strong humoral and cell-mediated immune responses Reprint Icon - (Peer Reviewed Journal)
Tuo, W., Zarlenga, D.S., Bakshi, M., Vinyard, B.T. 2021. Repeated, drug-truncated infections with Ostertagia ostertagi elicit strong humoral and cell-mediated immune responses. Veterinary Parasitology. 296:109510. https://doi.org/10.1016/j.vetpar.2021.109510.
Ostertagia ostertagi mediates early host immune responses via macrophage and Toll like receptor pathways Reprint Icon - (Peer Reviewed Journal)
Bakshi, M., Hebert, D.A., Gulbronson, C., Bauchan, G.R., Tuo, W., Zarlenga, D.S. 2021. Ostertagia ostertagi mediates early host immune responses via macrophage and Toll like receptor pathways. Infection and Immunity. 1-42. https://doi.org/10.1128/IAI.00017-21.
Editorial: Immunoparasitology: A unique interplay between host and pathogen Reprint Icon - (Peer Reviewed Journal)
Suo, X., Wu, Z., Lillehoj, H.S., Tuo, W. 2020. Editorial: Immunoparasitology: A unique interplay between host and pathogen. Frontiers in Immunology. 11:880. https://doi.org/10.3389/fimmu.2020.00880.
Immunoproteomic and mass spectrometric analysis of Eimeria acervulina antigens recognized by antisera from chickens infected with E. acervulina, E. tenella or E. necatrix Reprint Icon - (Peer Reviewed Journal)
Liu, J., Tuo, W., Wu, X., Xiong, J., Yu, E., Yin, C., Ma, Z., Liu, L. 2020. Immunoproteomic and mass spectrometric analysis of Eimeria acervulina antigens recognized by antisera from chickens infected with E. acervulina, E. tenella or E. necatrix. Veterinary Parasitology. 13:93. https://doi.org/10.1186/s13071-020-3965-y.
Characterization of IL-10-producing neutrophils in cattle infected with Ostertagia ostertagi Reprint Icon - (Peer Reviewed Journal)
Li, L., Si, H., Wu, S., Mendez, J.O., Zarlenga, D.S., Tuo, W., Xiao, Z. 2019. Characterization of IL-10 producing neutrophils in cattle infected with Ostertagia ostertagi. Scientific Reports. 9:20292. https://doi.org/10.1038/s41598-019-56824-x.
TRPV4 is dispensable for the development of airway allergic asthma Reprint Icon - (Peer Reviewed Journal)
Palaniyandi, S., Rajendrakumar, A.M., Periasamy, S., Goswami, R., Tuo, W., Zhu, X., Rahaman, S.O. 2019. TRPV4 is dispensable for the development of airway allergic asthma. Laboratory Investigation. https://doi.org/10.1038/s41374-019-0305-y.
Neospora caninum dynein LC8 light chain 2 is identical to that of Toxoplasma gondii and differentially produced by pathogenically distinct isolates Reprint Icon - (Peer Reviewed Journal)
Cao, L., Qu, G., Fetterer, R.H., Zhang, X., Tuo, W. 2019. Neospora caninum dynein LC8 light chain 2 is identical to that of Toxoplasma gondii and differentially produced by pathogenically distinct isolates. Parasitology. https://doi.org/10.1017/S003118201800207X.
Bovine neutrophils form extracellular traps in response to the gastrointestinal parasite Ostertagia ostertagi Reprint Icon - (Peer Reviewed Journal)
Mendez, J., Sun, D., Tuo, W., Zhengguo, X. 2018. Bovine neutrophils form extracellular traps in response to the gastrointestinal parasite Ostertagia ostertagi. Scientific Reports. 8:17598. https://doi.org/10.1038/s41598-018-36070-3
A tale of three kingdoms: members of the Phylum Nematoda independently acquired the detoxifying enzyme cyanase through horizontal gene transfer from plants and bacteria Reprint Icon - (Peer Reviewed Journal)
Zarlenga, D.S., Mitreva, M., Thompson, P., Tyagi, R., Tuo, W., Hoberg, E.P. 2018. A tale of three kingdoms: members of the Phylum Nematoda independently acquired the detoxifying enzyme cyanase through horizontal gene transfer from plants and bacteria. Parasitology. 146(4):445-452. https://doi.org/10.1017/S0031182018001701.
Characterization of an Ostertagia ostertagi annexin-like protein at different developmental stages Reprint Icon - (Peer Reviewed Journal)
Tuo, W., Sharma, P., Tuo, J., Jenkins, M.C., Zarlenga, D.S., Xiao, Z., Fetterer, R.H. 2017. Characterization of an Ostertagia ostertagi annexin-like protein at different developmental stages. Parasitology Research. 116:1515-1522.
Comparative analysis of bovine abomasal mucosal immune responses resulting from pasture/grass or grain feeding - (Peer Reviewed Journal)
Tuo, W., Li, L., Lv, Y., Brown, D., Davis, W., Song, J., Zarlenga, D.S., Xiao, Z. 2016. Comparative analysis of bovine abomasal mucosal immune responses resulting from pasture/grass or grain feeding. Veterinary Parasitology. 229:118-125.
The identification of Haemonchus species and diagnosis of Haemonchosis - (Peer Reviewed Journal)
Zarlenga, D.S., Hoberg, E.P., Tuo, W. 2016. The identification of Haemonchus species and diagnosis of Haemonchosis. Advances in Parasitology. 93:145-180. doi.org/10.1016/bs.apar.2016.02.023.
QS-21: a potent vaccine adjuvant ()
Tuo, W., Zhu, D. 2016. QS-21: a potent vaccine adjuvant. Comprehensive Natural Products Chemistry. 3(4):e113.
A two-step method to purify Ostertagia ostertagi eggs from feces: Sucrose flotation followed by density gradient centrifugation using lymphocyte separation medium - (Peer Reviewed Journal)
Tuo, W., Zarlenga, D.S., Hebert, D.A., Miramontes, E.N., Fetterer, R.H. 2015. A two-step method to purify Ostertagia ostertagi eggs from feces: Sucrose flotation followed by density gradient centrifugation using lymphocyte separation medium. Comparative Parasitology. 82(2):275-279.
Characterization of the Eimeria maxima sporozoite surface protein IMP1 - (Peer Reviewed Journal)
Jenkins, M.C., Fetterer, R.H., Miska, K.B., Tuo, W., Kwok, O.C., Dubey, J.P. 2015. Characterization of the Eimeria maxima sporozoite surface protein IMP1. Veterinary Parasitology. doi: 10.1016/jvetpar2015.05.009.
Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of airway allergic inflammation - (Peer Reviewed Journal)
Palaniyandi, S., Liu, X., Periyasamy, S., Ma, A., Jenkins, M.C., Tuo, W., Song, W., Keegan, A.D., Conrad, D.H., Zhu, X. 2015. Inhibition of CD23-mediated IgE transcytosis suppresses the initiation and development of airway allergic inflammation. Mucosal Immunology. DOI:10.1038/mi.2015.16.
Detection and survival of Toxoplasma gondii in milk and cheese from experimentally infected goats Reprint Icon - (Peer Reviewed Journal)
Dubey, J.P., Verma, S., Ferreira, L., Cassinelli, A., Yuging, Y., Kwok, O.C., Tuo, W., Chiesa, O., Jones, J. 2014. Detection and survival of Toxoplasma gondii in milk and cheese from experimentally infected goats. Journal of Food Protection. 77:1747–1753.
Ostertagia ostertagi macrophage migration inhibition factor is present at all developmental stages and may cross-regulate host functions through host receptor - (Peer Reviewed Journal)
Qu, G., Fetterer, R.H., Leng, L., Du, X., Zarlenga, D.S., Shen, Z., Han, W., Bucala, R., Tuo, W. 2014. Ostertagia ostertagi macrophage migration inhibition factor is present at all developmental stages and may cross-regulate host functions through host receptor. International Journal for Parasitology. 44(6):355-367.
Characterization of Neospora caninum macrophage migration inhibitory factor - (Peer Reviewed Journal)
Qu, G., Fetterer, R.H., Jenkins, M.C., Leng, L., Shen, Z., Murphy, C.A., Han, W., Bucala, R., Tuo, W. 2013. Characterization of Neospora caninum macrophage migration inhibitory factor. Experimental Parasitology. 135(2):246-256.
Parasiticidal activity of a novel synthetic peptide from the core a-helical region of NK-lysin Reprint Icon - (Peer Reviewed Journal)
Citation: Lee, SH, Lillehoj, HS, Tuo, W., Murphy, CA, Hong, YH, Lillehoj, EP. 2013. Parasiticidal activity of a novel synthetic peptide from the core a-helical region of NK-lysin. Veterinary Parasitology 197:113-121.
Neospora caninum surface antigen (p40) is a potential diagnostic marker for cattle neosporosis Reprint Icon - (Peer Reviewed Journal)
Hu, P., Li, J., Gong, P., Liu, C., Zhang, G., Yang, J., Tuo, W., Yang, B., Zhang, X. 2013. Neospora caninum surface antigen (p40) is a potential diagnostic marker for cattle neosporosis. Parasitology Research. 112(5):2117-2120.
TLR agonists are highly effective at eliciting functional memory CTLs of effector memory phenotype in peptide immunization - (Peer Reviewed Journal)
Smyth, K., Garcia, K., Sun, Z., Tuo, W., Xiao, Z. 2012. TLR agonists are highly effective at eliciting functional memory CTLs of effector memory phenotype in peptide immunization. International Immunopharmacology. 15:67-72.
Repetitive peptide boosting progressively enhances functional memory CTLs - (Peer Reviewed Journal)
Smyth, K., Garcia, K., Sun, Z., Tuo, W., Xiao, Z. 2012. Repetitive peptide boosting progressively enhances functional memory CTLs. Biochemical and Biophysical Research Communications. 424(3):635-640.
Strategies to identify microRNA targets: New advances - (Peer Reviewed Journal)
Jin, H., Tuo, W., Lian, H., Liu, Q., Gao, H., Zhu, X. 2011. Strategies to identify microRNA targets: New advances. New Biotechnology. 27(6):734-734-738.
Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection - (Peer Reviewed Journal)
Li, Z., Palaniyandi, S., Zeng, R., Tuo, W., Roopenian, D., Zhu, X. 2011. Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection. Proceedings of the National Academy of Sciences. 108(11):4388-4393.
Tunicamycins, a class of nucleoside antibiotics similar to corynetoxins of the Rathayibactor toxicus, increase susceptibility of mice to Neospora caninum - (Peer Reviewed Journal)
Tuo, W., Zhang, X., Cao, L. 2010. Tunicamycins, a class of nucleoside antibiotics similar to corynetoxins of the Rathayibactor toxicus, increase susceptibility of mice to Neospora caninum. Veterinary Parasitology. 177(1-2):13-29.
microRNAs of parasites: current status and future perspectives - (Peer Reviewed Journal)
Liu, Q., Tuo, W., Gao, H., Zhu, X. 2010. microRNAs of parasites: current status and future perspectives. Parasitology Research. 107:501-507.
Neospora caninum tachyzoite- and antigen-stimulated production of cytokines by enriched bone marrow-derived dendritic cells and spleen cells of naive BALB/c mice - (Peer Reviewed Journal)
Feng, X., Zhang, N., Tuo, W. 2010. Neospora caninum tachyzoite- and antigen-stimulated production of cytokines by enriched bone marrow-derived dendritic cells and spleen cells of naive BALB/c mice. Journal of Parasitology. 96(4):717-723.
Neospora caninum: Cloning and expression of a gene coding for cytokine-inducing Neospora caninum profilin - (Peer Reviewed Journal)
Jenkins, M.C., Tuo, W., Feng, X., Cao, L., Murphy, C.A., Fetterer, R.H. 2010. Neospora caninum: Cloning and expression of a gene coding for cytokine-inducing Neospora caninum profilin. Experimental Parasitology. 125:357-362.
Fetal death in cows experimentally infected with Neospora caninum at 110 days of gestation - (Peer Reviewed Journal)
Almeria, S., Araujo, R., Tuo, W., Lopez-Gatius, F., Dubey, J.P., Gasbarre, L.C. 2010. Fetal death in cows experimentally infected with Neospora caninum at 110 days of gestation. Veterinary Parasitology. 169:304-311.
Comparative gene expression profiling of Neospora caninum strains - (Peer Reviewed Journal)
Li, R.W., Tuo, W. 2010. Comparative gene expression profiling of Neospora caninum strains. Experimental Parasitology. 129:346-354.
Giardia canis: ultrastructural analysis of G. canis trophozoites transfected with full length G. canis virus cDNA transcripts - (Peer Reviewed Journal)
Cao, L., Gong, P., Li, J., Zhang, X., Zou, X., Tuo, W., Liu, Q., Wang, Q., Zhang, G., Chen, L., Li, L., Su, L. 2009. Giardia canis: ultrastructural analysis of G. canis trophozoites transfected with full length G. canis virus cDNA transcripts. Experimental Parasitology. 123:212-217.
VACCINATION OF FEMALE BALB/C MICE WITH NEOSPORA CYCLOPHILIN AND/OR NCSRS2 ELICITS SPECIFIC ANTIBODY RESPONSE AND PREVENTS AGAINST CHALLENGE INFECTION BY NEOSPORA CANINUM - (Abstract Only)
Tuo, W., Zhao, Y., Zhu, D., Jenkins, M.C. 2008. Vaccination of female balb/c mice with neospora cyclophilin and/or ncsrs2 elicits specific antibody response and prevents against challenge infection by neospora caninum. AAAVP Meeting in New Orleans, LA, 07/19-22/2008.
INTERFERON-GAMMA STIMULATING ACTIVITIES OF THE FRACTIONATED NEOSPORA CANINUM TACHYZOITE LYSATE - (Abstract Only)
Feng, X., Fetterer, R.H., Tuo, W. 2008. Interferon-gamma stimulating activities of the fractionated neospora caninum tachyzoite lysate. BARC Poster Day.
Identification and characterization of a novel splicing variant of the MHC class 1-related neonatal Fe receptor for IgG. - (Peer Reviewed Journal)
Ye, L., Tuo, W., Liu, X., Zhu, X. 2008. Identification and characterization of an alternatively spliced variant of the MHC class I-related porcine neonatal Fc receptor for IgC. Dev Comp Immunol. 32(8):966-79. PMID:18321573
Neosporosis in Beagle dogs clinical signs, diagnosis, treatment, isolation and genetic characterization of Neospora caninum. - (Peer Reviewed Journal)
Dubey, J.P., Vianna M, C.R., Kwok, O.C., Hill, D.E., Miska, K.B., Tuo, W., Velmurugan, G.V., Conors, M., Jenkins, M.C. 2007. Neosporosis in Beagle dogs clinical signs, diagnosis, treatment, isolation and genetic characterization of Neospora caninum. Veterinary Parasitology. 149:158-166.
Immunomodulatory Effects of Safflower Leaf (Carthamus tinctorius) - (Peer Reviewed Journal)
Lee, S., Lillehoj, H.S., Heckert, R.A., Chun, H., Cho, S., Tuo, W. 2008. Immunomodulatory Effects of Safflower Leaf (Carthamus tinctorius)on Chicken lymphocytes and macrophages. Journal of Poultry Science. 45:147-151
Identification and characterization of a novel splicing variant of the MHC classI-related Neonatal Fc receptor for IgG - (Abstract Only)
Ye, L., Tuo, W., Liu, X., Zhu, X. 2007. Identification and characterization of a novel splicing variant of the MHC classI-related Neonatal Fc receptor for IgG. Meeting Abstract.
Molecular cloning and characterization of chicken NK lysin - (Peer Reviewed Journal)
Hong, Y.H., Lillehoj, H.S., Dalloul, R.A., Miska, K.B., Tuo, W., Lee, S., Han, J., Lillehoj, E.P. 2006. Molecular cloning and characterization of chicken NK lysin. Infection and Immunity. 110:339-347.
NK-LYSIN: HIGH LEVEL OF LOCAL GENE EXPRESSION IN COCCIDIOSIS - (Abstract Only)
Lillehoj, H.S., Hong, Y.H., Dalloul, R.A., Miska, K.B., Tuo, W., Lee, S., Han, J., Lillehoj, E.P. 2006. Nk-lysin: high level of local gene expression in coccidiosis.May 12-16, Boston, MA. P43.
NEOSPORA CANINUM CYCLOPHILIN: A INTERFERON-GAMMA-INDUCING PROTEIN THAT MAY MEDIATE THE PARASITE-HOST INTERACTIONS. - (Abstract Only)
Tuo, W., Fetterer, R.H., Jenkins, M.C., Dubey, J.P. 2005. Neospora caninum cyclophilin: a interferon-gamma-inducing protein that may mediate the parasite-host interactions.. Meeting Abstract.
NEOSPORA CANINUM IMMUNOPHILIN STIMULATES INTERFERON-GAMMA PRODUCTION - (Abstract Only)
Tuo, W., Fetterer, R.H., Jenkins, M.C., Dubey, J.P. 2005. Neospora caninum immunophilin stimulates interferon-gamma production. Meeting Abstract.
IDENTIFICATION AND CHARACTERIZATION OF NEOSPORA CANINUM CYCLOPHILIN THAT ELICITS INTERFERON-GAMMA PRODUCTION - (Peer Reviewed Journal)
Tuo, W., Fetterer, R.H., Jenkins, M.C., Dubey, J.P. 2005. Identification and characterization of Neospora caninum cyclophilin that elicits interferon-gamma production. Infection and Immunity. 73(8):5093-5100.
NEOSPORA CANINUM ANTIGEN DEFINED BY ANTIGEN-DEPENDENT BOVINE CD4+ T CELLS - (Peer Reviewed Journal)
Tuo, W., Fetterer, R.H., Jenkins, M.C., Dubey, J.P. 2005. Neospora caninum antigen defined by antigen-dependent bovine cd4+ t cells. Journal of Parasitology 91(3):564-568.
VACCINATION OF SHEEP WITH NEOSPORA CANINUM PROTEIN PRODUCTS AGAINST FETAL LOSS ASSOCIATED WITH EXPERIMENTAL NEOSPOROSIS - (Peer Reviewed Journal)
Jenkins, M.C., Tuo, W., Dubey, J.P. 2004. Vaccination of sheep with neospora caninum protein products against fetal loss associated with experimental neosporosis. American Journal of Veterinary Research 65:1404-1408.
EXPERIMENTAL INFECTION OF PREGNANT COWS WITH NEOSPORA CANIUM: HISTOLOGICAL ANALYSIS AND PARASITE DETECTION IN DAM AND FETUS - (Abstract Only)
Almeria, S., Araujo, R., Tuo, W., Dubey, J.P., Gasbarre, L.C. 2004. Experimental infection of pregnant cows with neospora canium: histological analysis and parasite detection in dam and fetus [abstract]. American Association of Veterinary Parasitologists Proceedings. p. 24
PROGRESS ON DEVELOPING A NATIVE RECOMBINANT VACCINE AGAINST BOVINE NEOSPOROSIS - (Abstract Only)
Jenkins, M.C., Tuo, W., Dubey, J.P. 2004. Progress on developing a native recombinant vaccine against bovine neosporosis. Annual Meeting of American Society of Parasitologists, p. 84.
IN SEARCH OF IMMUNODOMINANT NEOSPORA CANINUM ANTIGENS USING IMMUNOLOGIC AND PROTEOMICS TECHNOLOGIES - (Abstract Only)
Tuo, W., Fetterer, R.H., Davis, B., Jenkins, M.C., Dubey, J.P. 2005. In search of immunodominant neospora caninum antigens using immunologic and proteomics technologies. 15th Annual BARC Poster Day, p. 51.
FUNCTIONAL CHARACTERIZATION OF HPLC-FRACTIONATED NEOSPORA CANINUM PROTEINS. - (Abstract Only)
Tuo, W., Fetterer, R.H., Jenkins, M.C., Dubey, J.P. 2004. Functional characterization of hplc-fractionated neospora caninum proteins. American Association of Veterinary Parasitologists p. 123.
PRION TRANSPORT ACROSS THE PLACENTA. - (Abstract Only)
Tuo, W. 2004. Prion transport across the placenta.. Journal of Reproductive Immunology 51, p. 408.
ESTABLISHMENT OF SHORT-TERM CD4+ T CELL LINES RECOGNIZING NEOSPORA CANINUM ANTIGEN - (Peer Reviewed Journal)
Tuo, W., Davis, W., Fetterer, R.H., Jenkins, M.C., Boyd, P., Gasbarre, L.C., Dubey, J.P. 2003. Establishment of short-term cd4+ T cell lines recognizing Neospora caninum antigen. Parasite Immunology. 26:243-246.
BOVINE T CELL RESPONSE TO ANTIGENS OF NEOSPORA CANINUM - (Abstract Only)
Tuo, W., Fetterer, R.H., Boyd, P., Gasbarre, L.C., Dubey, J.P. 2003. Bovine T-cell response to antigens of neospora caninum. 2003. ARS Immunology Research Workshop. December 1-4, 2003, Bethesda, MD. p. 9.
IMMUNOLOGICAL AND MOLECULAR STRATEGIES TO CONTROL NEOSPOROSIS IN CATTLE - (Abstract Only)
Tuo, W., Dubey, J.P., Gasbarre, L.C., Jenkins, M.C., Zarlenga, D.S., Fetterer, R.H., Dyer, R., Boyd, P., Paape, M.J. 2003. Immunological and molecular strategies to control neosporosis in cattle. BARC Poster Day.
PREGNANCY STATUS AND FETAL PRION GENETICS DETERMINE PRPSC ACCUMULATION IN PLACENTOMES OF SCRAPIE INFECTED SHEEP - (Peer Reviewed Journal)
Tuo, W., O'Rourke, K.I., Zhuang, D., Cheevers, W., Spraker, T., Knowles, Jr., D.P. 2002. Pregnancy status and fetal prion genetics determine PrPSc accumulation in placentomes of scrapie infected sheep. Proceedings of the National Academy of Sciences. 99(9):6310-6315.
THE AGE RELATED INNATE IMMUNE RESPONSE IN CALVES TO BABESIA BOVIS INVOLVES IL-12 INDUCTION AND IL-10 MODULATION - (Peer Reviewed Journal)
PRP-C AND PRP-SC AT THE FETAL-MATERNAL INTERFACE - (Peer Reviewed Journal)
THE PREDOMINANT ISOFORM OF OVINE PLACENTAL AND UTERINE PRP IS PROTEINASE K SENSITIVE, N-TERMINAL TRUNCATED AND GLYCOSYLATED - (Abstract Only)
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