Microbial-derived products as potential new antimicrobials

Authors: SEALE, BRUCE - Oregon State University; DRYDER, DJAMEL - Universite De Lille; OAKLEY, BRUCE - Western University Of Health Sciences; BRUSSOW, HARALD - Nestle; BIKARD, DAVID - Institut Pasteur - France; Rich, Joseph; MILLER, STEFAN - Lisando Gmbh; DEVILLARD, ESTELLE - Adisseo France Sas; KWAN, JASON - University Of Wisconsin; BERTIN, GERARD - European Probiotic Association; REEVES, STUART - Embria Health Sciences; SWIFT, STEVEN - Retired ARS Employee; RAICEK, MARGOT - World Organization For Animal Health; Gay, Cyril

Submitted to: Veterinary Research
Publication Type: Review Article
Publication Acceptance Date: 2/1/2018
Publication Date: 7/31/2018
Citation: Seale, B., Dryder, D., Oakley, B.B., Brussow, H., Bikard, D., Rich, J.O., Miller, S., Devillard, E., Kwan, J., Bertin, G., Reeves, S., Swift, S.M., Raicek, M., Gay, C.G. 2018. Microbial-derived products as potential new antimicrobials. Veterinary Research. 49:66-78.

Interpretive Summary: This publication is the review of a series of presentations at the Headquarters of the World Organization for Animal Health (OIE) in Paris, France during December 12-16, 2016. This review summarizes presentations given during the Microbial-derived Products session wherein several topics were discussed including novel use of a gene editing system to act as sequence specific antimicrobials, pro-biotic development via fecal transplantation in poultry, microbial-ecology driven discovery of antimicrobial compounds and other traditional sources of discovering novel antimicrobial compounds from microbial sources.

Technical Abstract: Due to the continuing global concerns involving antibiotic resistance, there is a need for scientific forums to assess advancements in the development of antimicrobials and their alternatives that might reduce development and spread of antibiotic resistance among bacterial pathogens. The objectives of the 2nd International Symposium on Alternatives to Antibiotics were to highlight promising research results and novel technologies that can provide alternatives to antibiotics for use in animal health and production, assess challenges associated with their authorization and commercialization for use, and provide actionable strategies to support their development. The session on microbial-derived products was directed at presenting novel technologies that included exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials, probiotics development via fecal microbiome transplants among monogastric production animals such as chickens and mining microbial sources such as bacteria or yeast to identify new antimicrobial compounds. Other research has included continuing development of antimicrobial peptides such as newly discovered bacteriocins as alternatives to antibiotics, use of bacteriophages accompanied by development of unique lytic proteins with specific cell-wall binding domains and novel approaches such as microbial-ecology guided discovery of anti-biofilm compounds discovered in marine environments. The symposium was held at the Headquarters of the World Organization for Animal Health (OIE) in Paris, France during 12–15 December 2016.